Formulation and evaluation of stomach-specific amoxicillin-loaded carbopol-934P mucoadhesive microspheres for anti-Helicobacter pylori therapy

Journal of Microencapsulation
Jayvadan K Patel, Jayant R Chavda

Abstract

The purpose of this research was to formulate and systemically evaluate in vitro and in vivo performances of mucoadhesive amoxicillin microspheres for the potential use in the treatment of gastric and duodenal ulcers, which were associated with Helicobacter pylori. Amoxicillin mucoadhesive microspheres containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier polymer were prepared by an emulsion-solvent evaporation technique. Results of preliminary trials indicate that quantity of emulsifying agent, time for stirring, drug-to-polymers ratio and speed of rotation affected the characteristics of microspheres. Microspheres were discrete, spherical, free flowing and showed a good percentage of drug entrapment efficiency. An in vitro mucoadhesive test showed that amoxicillin mucoadhesive microspheres adhered more strongly to the gastric mucous layer and could retain in the gastrointestinal tract for an extended period of time. A 3(2) full factorial design was employed to study the effect of independent variables, drug-to-polymer-to-polymer ratio (amoxicillin-ethyl cellulose-carbopol-934P) (X(1)) and stirring speed (X(2)) on dependent variables, i.e. percentage mucoadhesion, drug entrapment efficiency, particle ...Continue Reading

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Citations

Jun 21, 2011·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Ganesh RajputJayvadan Patel
Jun 28, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Daniela LopesSalette Reis
Sep 29, 2015·Pharmaceutical Development and Technology·Farnaz MonajjemzadehMitra Jelvehgari
Nov 30, 2012·Journal of Microencapsulation·Sree HarshaArshia Shariff
Aug 13, 2020·Dose-response : a Publication of International Hormesis Society·Tahani S BasahihOsama A A Ahmed
Nov 2, 2017·Expert Review of Gastroenterology & Hepatology·Darren Michael MossAndrew Owen

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