Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

Pharmaceutics
Maria LazaridouDimitrios N Bikiaris

Abstract

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles with a size ranging between 150 and 400 nm were prepared for neat CS/TPP with a 2/1 molar ratio while their yield was directly dependent on the applied stirring rate during the preparation process. DFO at different content (20, 45 and 75 wt %) was encapsulated into these nanoparticles. We found that drug loading correlates with increasing DFO content while the entrapment efficiency has an opposite behavior due to the high solubility of DFO. Hydrogen-bonding between amino and hydroxyl groups of DFO with reactive groups of CS were detected using FT-IR spectroscopy while X-ray diffraction revealed that DFO was entrapped in amorphous form in the CS nanoparticles. DFO release is directly dependent on the content of loaded drug, while model analysis revealed that the release mechanism of DFO for the CS/TPP nanoparticles is by diffusion. Treatment of murine RAW 264.7 macrophages with nanoencapsulated DFO promoted an increased expression of tr...Continue Reading

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Citations

May 5, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Fang DingHaihua Xiao
Aug 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nina Maria AinaliDimitrios N Bikiaris
May 3, 2020·Polymers·Marion ClaverieSusana C M Fernandes
Apr 6, 2021·Neural Regeneration Research·Eniko Manek, Georg A Petroianu
May 23, 2021·Drug Delivery and Translational Research·Pratiksha PrabhuSujata P Sawarkar
Jun 10, 2021·ACS Chemical Biology·Usama AbbasiJayachandran N Kizhakkedathu
Jul 17, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahmoud Mohamed OmarMarc-André Fortin
Jul 13, 2021·International Journal of Pharmaceutics·A AbruzzoF Bigucci
Jan 16, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Emmanuel MathuthuShayne Mason

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Methods Mentioned

BETA
scanning
X-ray
scanning electron microscopy
dynamic light scattering
PCR

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