Formulation and in vitro evaluation of bisphosphonate loaded microspheres for implantation in osteolysis

Drug Development and Industrial Pharmacy
Sibel SamdanciogluA Atilla Hincal

Abstract

Chitosan and poly(lactide-co-glycolide) acid (PLGA) microspheres loaded with alendronate sodium (AS) were prepared for orthopedic as well as dental applications. In orthopedics the aim was to make the total joint prostheses stay in the body for a long time without causing bone tissue loss, while in dentistry it was aimed to treat the alveolar bone resorption caused by periodontitis and also to make the dental treatment using implants easier by reducing the bone loss in patients with osteoporosis. Solvent evaporation method was used to prepare AS loaded PLGA microspheres and emulsion polimerization method was used to prepare AS loaded chitosan microspheres. Particle size, loading efficacy, surface characteristics, and in vitro release characteristics were examined on prepared formulations. After the examination of the scanning electron microscopy photographs of microspheres, chitosan microspheres were observed to have spherical structure and smooth surface characteristics while PLGA microspheres were observed to have spherical porous surface structure. Loading efficacy was found to be 3.30% for chitosan microspheres and 7.70% for PLGA microspheres. It was observed that 85% of AS had been released at the end of the third day from...Continue Reading

References

Dec 1, 1994·Journal of Pharmaceutical Sciences·J H LinF A deLuna
Jan 1, 1997·Journal of Drug Targeting·S PatashnikG Golomb
Jan 7, 1999·Drug Development and Industrial Pharmacy·R JainC T Rhodes
Jan 20, 1999·Annals of the Rheumatic Diseases·A SabokbarN A Athanasou
Jun 6, 2000·Advanced Drug Delivery Reviews·J W McGinity, P B O'Donnell
Feb 13, 2001·International Journal of Pharmaceutics·H Fan, A K Dash
Jul 4, 2001·Drugs·M SharpeC M Spencer
Jan 5, 2002·Advanced Drug Delivery Reviews·W E Hennink, C F van Nostrum
Feb 28, 2002·The Journal of Bone and Joint Surgery. American Volume·Yuichi MochidaPhillip R Brown
Jan 20, 2004·AAPS PharmSciTech·P PeruginiF Pavanetto

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Citations

Jun 5, 2012·International Journal of Nanomedicine·Ji-Ho LimCheong-Weon Cho
Feb 2, 2013·International Journal of Pharmaceutical Investigation·Mohammad TariqJasjeet K Sahni
Jul 27, 2007·Journal of Microencapsulation·Eman H NafeaNawal M Khalafallah
Jul 13, 2012·Journal of Microencapsulation·Ji-Ho LimCheong-Weon Cho
Jul 15, 2015·Drug Development and Industrial Pharmacy·Yusuke HattoriMakoto Otsuka
Mar 4, 2010·Drug Delivery·Letícia CruzAdriana Raffin Pohlmann
Feb 3, 2007·Expert Opinion on Pharmacotherapy·Leena PalomoNabil F Bissada
May 19, 2010·Journal of Drug Targeting·Jong-Suep BaekCheong-Weon Cho
Feb 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elisabeth V GigerJean-Christophe Leroux
Feb 5, 2013·International Journal of Pharmaceutics·K MiladiA Elaissari
Aug 11, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Maha NasrNahed D Mortada
Jan 1, 2011·Pharmaceutics·Asteria Luzardo AlvarezJosé Blanco Méndez
Aug 1, 2014·Journal of Materials Science. Materials in Medicine·Hongwei WuChaoyue Zhang
Jul 8, 2020·Journal of Functional Biomaterials·Sofia S H Matrali, Anita K Ghag
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Rohith JayaramDavid A Puleo
Aug 26, 2011·Pharmaceutics·Asteria Luzardo ÁlvarezJosé Blanco Méndez

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