Formulation and Pharmacokinetic Evaluation of Phosal Based Zaltoprofen Solid Self-Nanoemulsifying Drug Delivery System

Pharmaceutical Nanotechnology
Rajan Kalamkar, Shailesh Wadher

Abstract

Phosal based excipients are liquid concentrates containing phospholipids. They are used to solubilize water-insoluble drug and also act as an emulsifier to get the smallest droplet size of the formed emulsion after administration. The aim is to prepare phosal based self nanoemulsifying drug delivery system (SNEDDS) for water insoluble drug zaltoprofen. The various parameters like solubility of drug in different vehicles, ternary phase diagram are considered to formulate the stable emulsion which is further characterized by Self emulsification time and globule size analysis to optimize liquid SNEDDS of Zaltoprofen. Optimized L-SNEDDS was converted into free-flowing powder Solid-SNEDDS (S-SNEDDS). S-SNEDDS was evaluated for Globule size analysis after reconstitution, in vitro dissolution study and in vivo pharmacokinetic study in rats. Phosal 53 MCT with highest drug solubility was used as oil along with Tween 80 and PEG 400 as surfactant and cosurfactant respectively to prepare liquid SNEDDS. Neusilin us2 was used as an adsorbent to get free-flowing S-SNEDDS. S-SNEDDS showed improved dissolution profile of the drug as compared to pure drug. In vivo study demonstrated that there is a significant increase in Cmax and AUC of S-SNED...Continue Reading

References

Feb 5, 2008·International Journal of Pharmaceutics·Ping ZhangJie Xu
Dec 23, 2008·Biomedical Chromatography : BMC·Hyun Kyoung YangHwa Jeong Lee
Mar 21, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Prabagar BalakrishnanHan-Gon Choi
Feb 9, 2010·Critical Reviews in Therapeutic Drug Carrier Systems·Bhupinder SinghO Katare
May 22, 2010·The Journal of Pharmacy and Pharmacology·Nahla S Barakat
Jul 28, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Saipin SetthacheewakulRuedeekorn Wiwattanapatapee
Aug 24, 2010·Drug Discovery Today·Kanchan KohliRoop K Khar
Jun 12, 2013·International Journal of Pharmaceutics·Jong-Suep BaekCheong-Weon Cho
Jun 19, 2013·AAPS PharmSciTech·N S Desai, M S Nagarsenker
Jan 13, 2015·Colloids and Surfaces. B, Biointerfaces·Anuj G AgrawalParaag S Gide
Apr 8, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Spandana InugalaSuresh Bandari
Jun 2, 2015·Chemical & Pharmaceutical Bulletin·Suparna Sacchit Bakhle, Jasmine Gev Avari
Feb 6, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R Nazari-VananiH Heli
Jul 18, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Peter van Hoogevest
Dec 10, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Taotao HuoHongtao Song

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