Formulation and Physicochemical Characterization of Cyclosporine Microfiber by Electrospinning

Advanced Pharmaceutical Bulletin
Shahla MirzaeeiKhosro Adibkia

Abstract

Purpose: The objective of this study was to improve the permeability and water solubility rate of a poor water soluble drug, cyclosporine A (CsA). Methods: In order to improve the drug dissolution rate and oral bioavailability, electrospinning method was used as an approach to prepare. The fibers were evaluated for surface morphology, thermal characterizations, drug crystallinity, in vitro drug release and in vivo bioavailability studies. Results: Scanning electron microscope (SEM) results confirmed that the fibers were in microsize range and the size of the fibers was in the rang of 0.2 to 2 micron. Differential scanning calorimetry (DSC) and powder X-ray diffractometry (XRPD) analysis ensured that the crystalline lattice of drug were weakened or destroyed in the fibers. The drug release was 15.28%, 20.67%, and 32.84% from pure drug, fibers of formulation B, and formulation A, respectively. In vivo study results indicated that the bioavailability parameters of the optimized fiber formulation were improved and the maximum concentration (Cmax) were significantly higher for fibers (3001 ng/mL) than for pure drug (2550 ng/mL). The dissolution rate of the formulations was dependent on the nature and ratio of drug to carriers. ...Continue Reading

References

Jun 6, 2000·Advanced Drug Delivery Reviews·J W McGinity, P B O'Donnell
May 5, 2001·International Journal of Pharmaceutics·E J LeeC K Kim
Nov 16, 2002·International Journal of Pharmaceutics·M H El-Shabouri
Oct 22, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jing ZengXiabin Jing
Apr 6, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jagdish JaiswalJorg Kreuter
May 27, 2005·Applied Biochemistry and Biotechnology·J Venugopal, S Ramakrishna
Dec 29, 2006·Drug Development and Industrial Pharmacy·Hadi ValizadehAli Nokhodchi
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ramesh C NagarwalJ K Pandit
Apr 21, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Satomi OnoueShizuo Yamada
Jun 30, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Vilasinee Hirunpanich, Hitoshi Sato
Aug 26, 2011·International Journal of Pharmaceutics·Keishi YamasakiHak-Kim Chan
Aug 14, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xue-Qing Wang, Qiang Zhang
Feb 23, 2013·International Journal of Pharmaceutics·Jwala RenukuntlaAshim K Mitra
Apr 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiuli HuXiabin Jing

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.