Formulation, in vitro and in vivo evaluation of transdermal patches containing risperidone

Drug Development and Industrial Pharmacy
Geeta AggarwalS L Hari Kumar

Abstract

The efficacy of oral risperidone treatment in prevention of schizophrenia is well known. However, oral side effects and patient compliance is always a problem for schizophrenics. In this study, risperidone was formulated into matrix transdermal patches to overcome these problems. The formulation factors for such patches, including eudragit RL 100 and eudragit RS 100 as matrix forming polymers, olive oil, groundnut oil and jojoba oil in different concentrations as enhancers and amount of drug loaded were investigated. The transdermal patches containing risperidone were prepared by solvent casting method and characterized for physicochemical and in vitro permeation studies through excised rat skin. Among the tested preparations, formulations with 20% risperidone, 3:2 ERL 100 and ERS 100 as polymers, mixture of olive oil and jojoba oil as enhancer, exhibited greatest cumulative amount of drug permeated (1.87 ± 0.09 mg/cm(2)) in 72 h, so batch ROJ was concluded as optimized formulation and assessed for pharmacokinetic, pharmacodynamic and skin irritation potential. The pharmacokinetic characteristics of the optimized risperidone patch were determined using rabbits, while orally administered risperidone in solution was used for comp...Continue Reading

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Citations

Sep 12, 2012·Schizophrenia Research and Treatment·Borah KimYoung-Chul Chung
Jan 10, 2014·Drug Development and Industrial Pharmacy·Wei GongXing-Guo Mei
Apr 29, 2014·Expert Opinion on Drug Delivery·Francesco CilurzoPaola Minghetti
Jan 26, 2016·International Journal of Pharmaceutics·Helen L QuinnRyan F Donnelly
Jul 15, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Panoraia I SiafakaDimitrios N Bikiaris
May 17, 2019·Drug Development and Industrial Pharmacy·Rajalakshmi RukmangathenPrasanna Raju Yalavarthi
Sep 8, 2019·CNS Drugs·Angela AbruzzoFederica Bigucci
May 24, 2020·Current Pharmaceutical Design·Ece Ö BülbülNeslihan Ü Okur
Sep 10, 2019·Journal of Pharmaceutical Sciences· AnnuJaved Ali
Nov 23, 2020·AAPS PharmSciTech·Faisal Al-AkaylehMayyas Al-Remawi
Jul 27, 2021·International Journal of Dermatology·Kesrin AmraFateh Khan

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