Formulation of a fast-dissolving ketoprofen tablet using freeze-drying in blisters technique

Drug Development and Industrial Pharmacy
Iman Saad AhmedF A Fatahalla

Abstract

The aim of this work was to develop a ketoprofen tablet which dissolve-rapidly in the mouth, therefore, needing not be swallowed. The solubility and dissolution rate of poorly water-soluble ketoprofen was improved by preparing a lyophilized tablet (LT) of ketoprofen using freeze-drying technique. The LT was prepared by dispersing the drug in an aqueous solution of highly water-soluble carrier materials consisting of gelatin, glycine, and sorbitol. The mixture was dosed into the pockets of blister packs and then was subjected to freezing and lyophilization. The saturation solubility and dissolution characteristics of ketoprofen from the LT were investigated and compared to the plain drug and the physical mixture (PM). Results obtained showed that the increase in solubility of ketoprofen from LT matrix, nearly three times greater than the solubility of the plain drug, was due to supersaturation generated by amorphous form of the drug. Results obtained from dissolution studies showed that LT of ketoprofen significantly improved the dissolution rate of the drug compared with the PM and the plain drug. More than 95% of ketoprofen in LT dissolved within 5 min compared to only 45% of ketoprofen plain drug dissolved during 60 min. Init...Continue Reading

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Citations

Mar 17, 2010·AAPS PharmSciTech·Khalid K AbedAlaa A Abdulrasool
Sep 11, 2012·AAPS PharmSciTech·Noorullah Naqvi MohammedMichael A Repka
Mar 17, 2011·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Aiman A Obaidat, Rana M Obaidat
Jun 21, 2011·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Bhatu P Badgujar, Atish S Mundada
Feb 20, 2020·Drug Delivery and Translational Research·Mohamed Ahmed El-NabarawiAmani M El Sisi
Feb 13, 2021·International Journal of Pharmaceutics·Phuong H L TranThao T D Tran
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sourav ThakurVijay Mishra

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