Formulation of a poorly water-soluble drug in sustained-release hollow granules with a high viscosity water-soluble polymer using a fluidized bed rotor granulator

International Journal of Pharmaceutics
Takumi AsadaShigeru Itai

Abstract

Water-soluble polymers with high viscosity are frequently used in the design of sustained-release formulations of poorly water-soluble drugs to enable complete release of the drug in the gastrointestinal tract. Tablets containing matrix granules with a water-soluble polymer are preferred because tablets are easier to handle and the multiple drug-release units of the matrix granules decreases the influences of the physiological environment on the drug. However, matrix granules with a particle size of over 800 μm sometimes cause a content uniformity problem in the tableting process because of the large particle size. An effective method of manufacturing controlled-release matrix granules with a smaller particle size is desired. The aim of this study was to develop tablets containing matrix granules with a smaller size and good controlled-release properties, using phenytoin as a model poorly water-soluble drug. We adapted the recently developed hollow spherical granule granulation technology, using water-soluble polymers with different viscosities. The prepared granules had an average particle size of 300 μm and sharp particle size distribution (relative width: 0.52-0.64). The values for the particle strength of the granules were ...Continue Reading

Citations

Sep 10, 2020·Drug Development and Industrial Pharmacy·Xiao LiuYanyan Jiang
Dec 29, 2019·Scientific Reports·Tadashi HattoriYasunori Iwao
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Edilene Gadelha de OliveiraRuy Carlos Ruver Beck
Nov 28, 2020·International Journal of Pharmaceutics·Hyun Wook HuhCheong-Weon Cho

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