Formulation of microemulsion systems for dermal delivery of silymarin.

AAPS PharmSciTech
Vipaporn PanapisalAngkana Tantituvanont

Abstract

Silymarin is a standardized extract from Silybum marianum seeds, known for its many skin benefits such as antioxidant, anti-inflammatory, and immunomodulatory properties. In this study, the potential of several microemulsion formulations for dermal delivery of silymarin was evaluated. The pseudo-ternary phase diagrams were constructed for the various microemulsion formulations which were prepared using glyceryl monooleate, oleic acid, ethyl oleate, or isopropyl myristate as the oily phase; a mixture of Tween 20®, Labrasol®, or Span 20® with HCO-40® (1:1 ratio) as surfactants; and Transcutol® as a cosurfactant. Oil-in-water microemulsions were selected to incorporate 2% w/w silymarin. After six heating-cooling cycles, physical appearances of all microemulsions were unchanged and no drug precipitation occurred. Chemical stability studies showed that microemulsion containing Labrasol® and isopropyl myristate stored at 40°C for 6 months showed the highest silybin remaining among others. The silybin remainings depended on the type of surfactant and were sequenced in the order of: Labrasol® > Tween 20® > Span 20®. In vitro release studies showed prolonged release for microemulsions when compared to silymarin solution. All release pro...Continue Reading

References

Mar 19, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Farrukh AfaqHasan Mukhtar
Dec 4, 2002·Advanced Drug Delivery Reviews·Mads Kreilgaard
Apr 16, 2003·International Journal of Pharmaceutics·Polona SpiclinMirjana Gasperlin
Mar 24, 2004·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Alena SvobodováDaniela Walterová
May 8, 2004·International Journal of Pharmaceutics·Ljiljana DjordjevicDanina Krajisnik
Sep 20, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vladimír Kren, Daniela Walterová
Oct 11, 2005·Archives of Pharmacal Research·Jaehwi LeeYoung Wook Choi
Oct 26, 2005·Skin Pharmacology and Physiology·A A DateM S Nagarsenker
Aug 1, 2006·International Journal of Pharmaceutics·Yue YuanDa-fang Zhong
Mar 3, 2007·Archives of Pharmacal Research·Jong Soo WooSang-Cheol Chi
Apr 28, 2007·Forschende Komplementärmedizin = Research in Complementary Medicine·Reinhard SallerRemy Meier
Aug 11, 2007·Journal of Dermatological Science·Alena SvobodováJitka Vostálová
Nov 13, 2007·International Immunopharmacology·Mi Hwa HanJong Soon Kang
Feb 29, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fabiana T M C VicentiniMaria J V Fonseca
May 2, 2009·The Journal of Pharmacy and Pharmacology·Soo-Jin ChooIck-Dong Yoo

❮ Previous
Next ❯

Citations

Feb 24, 2015·Drug Development and Industrial Pharmacy·Faiyaz Shakeel, Md Khalid Anwer
May 1, 2016·International Journal of Pharmaceutics·Airlla L M CavalcantiBolívar P G L Damasceno
Jan 8, 2017·Photochemistry and Photobiology·Mary K Montes de OcaFarrukh Afaq
Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alfonso Di Costanzo, Ruggero Angelico
Apr 5, 2020·Pharmaceutics·Julia ZhangBozena Michniak-Kohn
Jun 28, 2018·AAPS PharmSciTech·Ellison Neves de LimaDavi Pereira de Santana

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.