Formulation of oil-in-water β-carotene microemulsions: effect of oil type and fatty acid chain length

Food Chemistry
Shahin RoohinejadDavid J Burritt

Abstract

The impact of oil type and fatty acid chain length on the development of food-grade microemulsions for the entrapment of β-carotene was investigated. The microemulsion region of a ternary phase diagram containing short chain monoglycerides was larger than for di- and triglycerides when Tween 80 was used as surfactant. The cytotoxicity of microemulsions composed of a 30% monoglyceride oil, 20% Tween 80 and 50% aqueous buffer were evaluated using an in vitro cell culture model (human epithelial colorectal adenocarcinoma, Caco-2). The cytotoxicity test showed that the viability of Caco-2 cells against β-carotene microemulsions at concentrations of 0.03125% (v/v) was higher than 90%. This study suggests that short chain monoglycerides could be used with Tween 80 to prepare transparent β-carotene-encapsulated O/W microemulsions in the particle size range of 12-100 nm.

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Mar 5, 2016·Pharmaceutical Development and Technology·Kevin Ita
Jul 12, 2017·Journal of Agricultural and Food Chemistry·Yuting FanWallace Yokoyama
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Oct 13, 2017·Drug Development and Industrial Pharmacy·Lei WuHongfei Wu
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Apr 3, 2021·Antioxidants·Vaibhav Kumar MauryaSunil Pareek
May 1, 2021·Pharmaceutics·Cristina ScomoroscencoLudmila Otilia Cinteza

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