Formulation of resveratrol entrapped niosomes for topical use

Colloids and Surfaces. B, Biointerfaces
Daniel PandoCarmen Pazos

Abstract

A new approach to the formulation of resveratrol (RSV) entrapped niosomes for topical use is proposed in this work. Niosomes were formulated with Gelot 64 (G64) as surfactant, and two skin-compatible unsaturated fatty acids (oleic and linoleic acids), commonly used in pharmaceutical formulations, as penetration enhancers. Niosomes were prepared by two different methods: a thin film hydration method with minor modifications followed by a sonication stage (TFH-S), and an ethanol injection modified method (EIM). Niosomes prepared with the EIM method were in the range of 299-402 nm, while the TFH-S method produced larger niosomes in the range of 293-496 nm. Moreover, niosomes with higher RSV entrapment efficiency (EE) and better stability were generated by the EIM method. Ex vivo transdermal experiments, carried out in Franz diffusion cells on newborn pig skin, indicated that niosomes prepared by the EIM method were more effective for RSV penetration in epidermis and dermis (EDD), with values up to 21% for both penetration enhancers tested. The EIM method, which yielded the best RSV-entrapped niosomes, seems to be the most suitable for scaling up.

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Citations

Jan 23, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Shankar SwaminathanFrancesco Trotta
Jun 28, 2016·Expert Opinion on Drug Delivery·Eline DesmetJo Lambert
Apr 16, 2018·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Wilson R PoiDaniela A Brandini
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Sep 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Claudia RiccardiDaniela Montesarchio
Apr 30, 2020·International Journal of Nanomedicine·Heshu Sulaiman RahmanNoorjahan Banu Alitheen
Jan 17, 2020·ChemPlusChem·Noelia D MachadoDavid Díaz Díaz
Jan 22, 2021·Drug Delivery and Translational Research·Delly RamadonRyan F Donnelly
Apr 4, 2021·Journal of Clinical Medicine·Óscar EstupiñánRené Rodríguez
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhixi YuYixin Zhang

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