Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles

Colloids and Surfaces. B, Biointerfaces
H R KelidariAli Nokhodchi

Abstract

The aim of the current investigation was to prepare and evaluate the potential use of solid lipid nanoparticles for the dermal delivery of spironolactone (SP). The spironolactone loaded SLN (SP-SLN) was prepared by emulsion-solvent evaporation method followed by ultrasonication. The properties of obtained SLNs were characterized by photon correlation spectroscopy (PCS), scanning tunneling microscopy (STM) and differential scanning calorimetry. FT-IR was also used to investigate any interaction between SP and excipients in the molecular level during the preparation of SLNs. The performance of the formulations was investigated in terms of drug release, skin permeation and also the retention of drug by the skin. The SP-SLNs presented spherical shape with the mean diameter, zeta potential and entrapment efficiency of 88.9 nm, -23.9 mV and 59.86%, respectively. DSC study showed that SP alone encapsulated in SLNs was in the amorphous form. FT-IR analysis revealed that there were hydrogen bond interactions between the SP alone and SLN components. The dissolution results revealed that the drug release from SP-SLNs was at least 4.9 times faster than original SP within the first 30 min. The cumulative amount of SP penetrated through rat ...Continue Reading

References

Jul 29, 2006·International Journal of Pharmaceutics·I Limayem BlouzaH Fessi
Jan 19, 2011·Colloids and Surfaces. B, Biointerfaces·Carla VitorinoAlberto A C C Pais

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Citations

Jan 18, 2016·International Journal of Pharmaceutics·Tanem GarantiKa-Wai Wan
Jun 12, 2016·Colloids and Surfaces. B, Biointerfaces·Jafar AkbariAli Nokhodchi
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Małgorzata Geszke-Moritz, Michał Moritz
Jun 25, 2016·Journal of Microencapsulation·Ailar TupalHamed Hamishehkar
Nov 5, 2016·International Journal of Pharmaceutics·Rohan M ShahIan H Harding
Feb 22, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hamid Reza KelidariAli Nokhodchi
Dec 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ju-Heon KimCheong-Weon Cho
Jan 21, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ali Ahmadi TehraniVahid Ramezani
Jun 4, 2020·Nanomaterials·Aditya MurthyShrinivas Malekar
Dec 16, 2017·Journal of Cellular Biochemistry·Sara DaneshmandBizhan Malaekeh-Nikouei
Oct 21, 2018·Pharmaceutics·Vijay MishraJessica M Rosenholm
May 18, 2020·Biomolecules·Ryan D GabbardMichael G Kemp
Feb 18, 2020·Expert Opinion on Drug Delivery·Eliana B SoutoSheefali Mahant
Mar 20, 2019·Pharmaceutical Development and Technology·Parisa GhasemiyehSoliman Mohammadi-Samani
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mona QushawyAli Nasr
Aug 28, 2020·Drug Design, Development and Therapy·Parisa Ghasemiyeh, Soliman Mohammadi-Samani
Aug 15, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·B Dréno
Jun 20, 2017·Expert Opinion on Investigational Drugs·Christos C ZouboulisHarald P M Gollnick
Aug 24, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Eshant BhatiaRinti Banerjee
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Khadijeh KhezriSolmaz Maleki Dizaj

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