Formulation Strategies for Folate-Targeted Liposomes and Their Biomedical Applications

Pharmaceutics
Parveen KumarBo Liu

Abstract

The folate receptor (FR) is a tumor-associated antigen that can bind with folic acid (FA) and its conjugates with high affinity and ingests the bound molecules inside the cell via the endocytic mechanism. A wide variety of payloads can be delivered to FR-overexpressed cells using folate as the ligand, ranging from small drug molecules to large DNA-containing macromolecules. A broad range of folate attached liposomes have been proven to be highly effective as the targeted delivery system. For the rational design of folate-targeted liposomes, an intense conceptual understanding combining chemical and biomedical points of view is necessary because of the interdisciplinary nature of the field. The fabrication of the folate-conjugated liposomes basically involves the attachment of FA with phospholipids, cholesterol or peptides before liposomal formulation. The present review aims to provide detailed information about the design and fabrication of folate-conjugated liposomes using FA attached uncleavable/cleavable phospholipids, cholesterol or peptides. Advances in the area of folate-targeted liposomes and their biomedical applications have also been discussed.

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Citations

Mar 11, 2020·Pharmaceutics·Catarina Roma-RodriguesAlexandra R Fernandes
Feb 18, 2021·Nucleic Acid Therapeutics·Sumit GangopadhyayKiran R Gore
Oct 16, 2020·Journal of Biomaterials Science. Polymer Edition·Parveen KumarAruna Chhikara
Mar 30, 2021·Colloids and Surfaces. B, Biointerfaces·Arpan PradhanDulal Panda
May 27, 2020·Biochemistry·Xiangzhao AiLiangfang Zhang
Jun 22, 2021·ACS Pharmacology & Translational Science·Nour AlSawaftahGhaleb A Husseini
Aug 3, 2021·Frontiers in Pharmacology·Shuang LiJian-Xin Liu

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Methods Mentioned

BETA
xenografts
antisense oligodeoxynucleotides
transfection
xenograft

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