Formulation techniques for high dose dry powders

International Journal of Pharmaceutics
Ashlee D Brunaugh, Hugh D C Smyth

Abstract

Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the treatment of both local pulmonary conditions and systemic diseases. Though DPIs are widely used for the pulmonary deposition of potent bronchodilators, anticholinergics, and corticosteroids, there is growing interest in the utilization of this delivery system for the administration of high drug doses to the lungs, as made evident by recent regulatory approvals for anti-microbial, anti-viral and osmotic agents. However, the formulation of high dose DPIs carries several challenges from both a physiological and physicochemical standpoint. This review describes the various formulation techniques utilized to overcome the barriers associated with the pulmonary delivery of high dose powders.

Citations

Apr 25, 2019·Drug Development and Industrial Pharmacy·Mohammad A M MominShyamal C Das
Jul 16, 2020·British Journal of Pharmacology·Rachel Yoon Kyung ChangHak-Kim Chan
Dec 20, 2018·Pharmaceutics·Hao ZhongDefang Ouyang
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yukun ZhangZhidong Liu
Feb 27, 2021·Expert Opinion on Drug Delivery·Ashlee D BrunaughHugh Smyth
May 23, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Frederic TewesAlan B Watts
Oct 15, 2020·Expert Opinion on Drug Delivery·Nathalie WauthozKarim Amighi
Aug 29, 2021·Pharmaceutics·Li DingHugh D C Smyth
Aug 29, 2021·Journal of Pharmaceutical Sciences·Ashlee D BrunaughHugh D C Smyth

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