Formulations for intermittent release of parathyroid hormone (1-34) and local enhancement of osteoblast activities

Pharmaceutical Development and Technology
J H Jeon, D A Puleo

Abstract

The objective of these studies was to develop simple, implantable devices that intermittently release PTH(1-34) and thus could be used for locally stimulating bone formation. The formulations were based on the association polymer system of cellulose acetate phthalate and Pluronic F-127. Release profiles for intermittent devices showed five discrete peaks, whereas sustained devices exhibited zero-order kinetics. Osteoblastic activity was greater for cells intermittently treated with PTH(1-34) compared to sustained exposure. These controlled release devices delivering PTH(1-34) in an intermittent manner may be useful for affecting osteoblast activities in a localized area.

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Citations

May 30, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dinesh ThummuriV G M Naidu
Apr 23, 2015·Asian Pacific Journal of Tropical Medicine·Yan YangPeng-Qiu Li
Sep 15, 2014·Acta Biomaterialia·Laura KyllönenDavid Eglin
Jul 22, 2015·Journal of Pediatric Orthopedics. Part B·Yuan ZouDavid A Puleo
Jun 22, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Samantha J Wojda, Seth W Donahue

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