Formulations for microprojection/microneedle vaccine delivery: Structure, strength and release profiles

Journal of Controlled Release : Official Journal of the Controlled Release Society
Anthony P RaphaelMark A F Kendall

Abstract

To develop novel methods for vaccine delivery, the skin is viewed as a high potential target, due to the abundance of immune cells that reside therein. One method, the use of dissolving microneedle technologies, has the potential to achieve this, with a range of formulations now being employed. Within this paper we assemble a range of methods (including FT-FIR using synchrotron radiation, nanoindentation and skin delivery assays) to systematically examine the effect of key bulking agents/excipients - sugars/polyols - on the material form, structure, strength, failure properties, diffusion and dissolution for dissolving microdevices. We investigated concentrations of mannitol, sucrose, trehalose and sorbitol from 1:1 to 30:1 with carboxymethylcellulose (CMC), although mannitol did not form our micro-structures so was discounted early in the study. The other formulations showed a variety of crystalline (sorbitol) and amorphous (sucrose, trehalose) structures, when investigated using Fourier transform far infra-red (FT-FIR) with synchrotron radiation. The crystalline structures had a higher elastic modulus than the amorphous formulations (8-12GPa compared to 0.05-11GPa), with sorbitol formulations showing a bimodal distribution of...Continue Reading

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Citations

Jun 11, 2016·Journal of Drug Targeting·Hye-Rin JeongJung-Hwan Park
Aug 16, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaya M AryaMark R Prausnitz
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhuangzhi ZhuHao Wang
Apr 5, 2017·Annual Review of Chemical and Biomolecular Engineering·Mark R Prausnitz
Jun 25, 2020·Pharmaceutics·Antonio José GuillotAna Melero
Nov 1, 2018·Bioengineering & Translational Medicine·Monica B Perez CuevasMark R Prausnitz
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Helen VallhovAnnika Scheynius
Aug 3, 2020·Drug Delivery and Translational Research·Vahid AlimardaniMohammad Ashfaq
Nov 21, 2020·Pharmaceutics·Aravindram Attiguppe SeetharamAfrasim Moin
Oct 24, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parbeen SinghXu Zhang
Mar 10, 2021·Journal of Pharmaceutical Investigation·Jae Hwan Jung, Sung Giu Jin
May 10, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jessica C JoyceMark R Prausnitz
Dec 12, 2018·Advanced Drug Delivery Reviews·Yuqi ZhangZhen Gu
Aug 11, 2021·Advanced Drug Delivery Reviews·Tao ShengZhen Gu

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