Abstract
To develop novel methods for vaccine delivery, the skin is viewed as a high potential target, due to the abundance of immune cells that reside therein. One method, the use of dissolving microneedle technologies, has the potential to achieve this, with a range of formulations now being employed. Within this paper we assemble a range of methods (including FT-FIR using synchrotron radiation, nanoindentation and skin delivery assays) to systematically examine the effect of key bulking agents/excipients - sugars/polyols - on the material form, structure, strength, failure properties, diffusion and dissolution for dissolving microdevices. We investigated concentrations of mannitol, sucrose, trehalose and sorbitol from 1:1 to 30:1 with carboxymethylcellulose (CMC), although mannitol did not form our micro-structures so was discounted early in the study. The other formulations showed a variety of crystalline (sorbitol) and amorphous (sucrose, trehalose) structures, when investigated using Fourier transform far infra-red (FT-FIR) with synchrotron radiation. The crystalline structures had a higher elastic modulus than the amorphous formulations (8-12GPa compared to 0.05-11GPa), with sorbitol formulations showing a bimodal distribution of...Continue Reading
References
Apr 29, 1998·Annual Review of Physiology·J H CroweL M Crowe
Sep 1, 2000·International Journal of Pharmaceutics·W Wang
Apr 28, 2001·Advanced Drug Delivery Reviews·L Yu
Jul 20, 2005·Pharmaceutical Research·Stuart WardStephen J Ebbens
Sep 1, 2005·Biomedical Microdevices·Takaya MiyanoKatsumi Hanada
Jun 28, 2006·Journal of Pharmaceutical Sciences·Birju ShahArvind K Bansal
Feb 12, 2008·Biomaterials·Jeong W LeeMark R Prausnitz
May 27, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jeffrey D MeyerMark Cornell Manning
Sep 26, 2009·PloS One·Fu-Shi QuanSang-Moo Kang
Mar 17, 2010·Biomaterials·Michael L CrichtonMark A F Kendall
Apr 14, 2010·Pharmaceutical Research·Yeu-Chun KimMark R Prausnitz
Apr 28, 2010·PloS One·Germain J P FernandoMark A F Kendall
Jul 20, 2010·Nature Medicine·Sean P SullivanMark R Prausnitz
Jul 29, 2010·Small·Anthony P RaphaelMark A F Kendall
Oct 27, 2010·PloS One·Holly J CorbettMark A F Kendall
Mar 1, 2011·Applied Spectroscopy·Hidayatul A ZakariaRobert J Falconer
Mar 5, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xianfeng ChenMark A F Kendall
Apr 5, 2011·Biomaterials·Michael L CrichtonMark A F Kendall
May 4, 2011·Journal of Food Science·Sung-Ae JangKyung Bin Song
May 7, 2011·Drug Development and Industrial Pharmacy·Yukako ItoKanji Takada
May 24, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Sep 15, 2011·The Journal of Physical Chemistry. a·Tao DingRobert J Falconer
Feb 7, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kazuhiko MatsuoShinsaku Nakagawa
Jul 31, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hwee-Ing NgMark A F Kendall
Dec 25, 2012·Biomaterials·Michael L CrichtonMark A F Kendall
Dec 26, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anthony P RaphaelMark A F Kendall
Feb 2, 2013·Biomaterials·Mei-Chin ChenMing-Hung Ling
Feb 16, 2013·International Journal of Pharmaceutics·Lei GuoYunhua Gao
Jun 4, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marie G McGrathAnne Moore
Jul 13, 2013·Advanced Healthcare Materials·Peter C DeMuthPaula T Hammond
Jul 23, 2013·PloS One·Frances E PearsonMark A F Kendall
Nov 1, 2013·Advanced Healthcare Materials·Li YanXianfeng Chen
Dec 20, 2013·The Journal of Investigative Dermatology·Xiao-Nong WangMuzlifah Haniffa
Oct 7, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Celia L McNeillyMark A F Kendall
Dec 8, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eriketi Z LoizidouChris J Allender
Mar 12, 2015·Biological & Pharmaceutical Bulletin·Dan WuAkira Yamamoto
Citations
Jun 11, 2016·Journal of Drug Targeting·Hye-Rin JeongJung-Hwan Park
Aug 16, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaya M AryaMark R Prausnitz
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhuangzhi ZhuHao Wang
Mar 30, 2017·Lab on a Chip·Min WangChenjie Xu
Apr 5, 2017·Annual Review of Chemical and Biomolecular Engineering·Mark R Prausnitz
Sep 6, 2018·Drug Delivery·Jingbo YangLelun Jiang
Jun 25, 2020·Pharmaceutics·Antonio José GuillotAna Melero
Oct 5, 2019·Advanced Healthcare Materials·Ailin HouChuanbin Wu
Nov 1, 2018·Bioengineering & Translational Medicine·Monica B Perez CuevasMark R Prausnitz
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Helen VallhovAnnika Scheynius
Feb 12, 2017·PloS One·Jiyu LiLiang Liang
Aug 5, 2017·Pharmaceutics·Akihiko OnoNaoki Okada
Aug 3, 2020·Drug Delivery and Translational Research·Vahid AlimardaniMohammad Ashfaq
Nov 21, 2020·Pharmaceutics·Aravindram Attiguppe SeetharamAfrasim Moin
Oct 24, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parbeen SinghXu Zhang
Mar 10, 2021·Journal of Pharmaceutical Investigation·Jae Hwan Jung, Sung Giu Jin
May 10, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jessica C JoyceMark R Prausnitz
Dec 12, 2018·Advanced Drug Delivery Reviews·Yuqi ZhangZhen Gu
Jul 3, 2021·Pharmaceutics·Merima SirbubaloEdina Vranić
Aug 11, 2021·Advanced Drug Delivery Reviews·Tao ShengZhen Gu