PMID: 5328567Jul 22, 1966

Formylmethionine codon AUG as an initiator of polypeptide synthesis

Science
R E ThachP Doty

Abstract

Oligonucleotide messengers containing the sequence AUG at or near the 5' end of the chain stimulate the incorporation of N-formylmethionine,but not of free (unformylated) methionine. AUG is considerably more active in this regard than UUG, the other N-formylmethionine codon. The coding activity of subsequent in-phase triplets in the 3' direction from AUG is markedly stimulated by this codon.

Citations

Nov 1, 1968·Die Naturwissenschaften·S Ochoa
Feb 11, 1971·Biochimica Et Biophysica Acta·J C Brown, P Doty
Jan 1, 1969·Progress in Biophysics and Molecular Biology·M S Bretscher
Dec 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·D Kolakofsky, T Nakamoto
Dec 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A R MorganH G Khorana
Feb 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·M SalasS Ochoa
Mar 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J W Hershey, R E Thach
Jun 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·M A BerberichR F Goldberger
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·A E Economou, T Nakamoto
Aug 1, 1970·European Journal of Biochemistry·F Sala, H Küntzel
Sep 1, 1971·Angewandte Chemie·G Schreiber
Jun 28, 1968·Journal of Molecular Biology·S Riyasaty, J F Atkins
May 14, 1968·Journal of Molecular Biology·J M Adams
Jan 1, 1980·CRC Critical Reviews in Biochemistry·P R Schimmel

Related Concepts

Carbon Isotopes
Alkalescens-Dispar Group
Formic Acids
Genetic Code
Hydrogen-Ion Concentration
Pedameth
Nucleotides
Polypeptides
Endorphenyl
Nuclear Track Detection

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.