PMID: 6987670Feb 1, 1980Paper

Formylmethionyl-tRNA alters RNA polymerase specificity

Proceedings of the National Academy of Sciences of the United States of America
P G DebenhamA A Travers

Abstract

Escherichia coli fMet-tRNAfMet alters the pattern of promoter selection of E. coli RNA polymerase (RNA nucleotidyltransferase, nucleosidetriphosphate:RNA nucleotidyltransferase; EC 2.7.7.6), affecting RNA synthesis from the rRNA, suIII+tRNA, and lac promoters in different ways. The in vitro synthesis of the stable RNA species is selectively decreased, whereas that of lac RNA from both the wild-type and mutant UV5 promoters is selectively increased at high ionic strength. The functional effect of fMet-tRNAfMet resembles that of the nucleotide guanosine 3'-diphosphate 5'-diphosphate (ppGpp). This nucleotide competes with the binding of fMet-tRnafMet to RNA polymerase.

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Citations

Jun 1, 1983·Die Naturwissenschaften·R Röhl
Sep 11, 1986·Nucleic Acids Research·T NomuraA Ishihama
May 24, 2003·Cold Spring Harbor Symposia on Quantitative Biology·C O GualerziC L Pon
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Sep 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Pohl MilonClaudio O Gualerzi
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Aug 12, 2015·Cellular and Molecular Life Sciences : CMLS·Claudio O Gualerzi, Cynthia L Pon
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Feb 16, 2021·Frontiers in Microbiology·He Cheng-Guang, Claudio Orlando Gualerzi
Dec 1, 1992·Journal of Bacteriology·N Mandal, U L RajBhandary

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