Fornix deep brain stimulation circuit effect is dependent on major excitatory transmission via the nucleus accumbens

NeuroImage
Erika K RossKendall H Lee

Abstract

Deep brain stimulation (DBS) is a circuit-based treatment shown to relieve symptoms from multiple neurologic and neuropsychiatric disorders. In order to treat the memory deficit associated with Alzheimer's disease (AD), several clinical trials have tested the efficacy of DBS near the fornix. Early results from these studies indicated that patients who received fornix DBS experienced an improvement in memory and quality of life, yet the mechanisms behind this effect remain controversial. It is known that transmission between the medial limbic and corticolimbic circuits plays an integral role in declarative memory, and dysfunction at the circuit level results in various forms of dementia, including AD. Here, we aimed to determine the potential underlying mechanism of fornix DBS by examining the functional circuitry and brain structures engaged by fornix DBS. A multimodal approach was employed to examine global and local temporal changes that occur in an anesthetized swine model of fornix DBS. Changes in global functional activity were measured by functional MRI (fMRI), and local neurochemical changes were monitored by fast scan cyclic voltammetry (FSCV) during electrical stimulation of the fornix. Additionally, intracranial micro...Continue Reading

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Citations

May 11, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Arvin AraniJohn Huston
Aug 10, 2019·Molecular Neurodegeneration·Danfang YuYunyun Han
Feb 25, 2017·Lab on a Chip·Helen N SchwerdtMichael J Cima
Nov 10, 2020·Journal of Alzheimer's Disease : JAD·Christopher B PopleNir Lipsman

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