Fornix Microstructure and Memory Performance Is Associated with Altered Neural Connectivity during Episodic Recognition
Abstract
The purpose of this study was to assess whether age-related differences in white matter microstructure are associated with altered task-related connectivity during episodic recognition. Using functional magnetic resonance imaging and diffusion tensor imaging from 282 cognitively healthy middle-to-late aged adults enrolled in the Wisconsin Registry for Alzheimer's Prevention, we investigated whether fractional anisotropy (FA) within white matter regions known to decline with age was associated with task-related connectivity within the recognition network. There was a positive relationship between fornix FA and memory performance, both of which negatively correlated with age. Psychophysiological interaction analyses revealed that higher fornix FA was associated with increased task-related connectivity amongst the hippocampus, caudate, precuneus, middle occipital gyrus, and middle frontal gyrus. In addition, better task performance was associated with increased task-related connectivity between the posterior cingulate gyrus, middle frontal gyrus, cuneus, and hippocampus. The findings indicate that age has a negative effect on white matter microstructure, which in turn has a negative impact on memory performance. However, fornix mi...Continue Reading
References
Differential age-related changes in the regional metencephalic volumes in humans: a 5-year follow-up
Citations
Splenial white matter integrity is associated with memory impairments in posterior cortical atrophy.
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