Fornix Microstructure and Memory Performance Is Associated with Altered Neural Connectivity during Episodic Recognition

Journal of the International Neuropsychological Society : JINS
Martina LyBarbara B Bendlin

Abstract

The purpose of this study was to assess whether age-related differences in white matter microstructure are associated with altered task-related connectivity during episodic recognition. Using functional magnetic resonance imaging and diffusion tensor imaging from 282 cognitively healthy middle-to-late aged adults enrolled in the Wisconsin Registry for Alzheimer's Prevention, we investigated whether fractional anisotropy (FA) within white matter regions known to decline with age was associated with task-related connectivity within the recognition network. There was a positive relationship between fornix FA and memory performance, both of which negatively correlated with age. Psychophysiological interaction analyses revealed that higher fornix FA was associated with increased task-related connectivity amongst the hippocampus, caudate, precuneus, middle occipital gyrus, and middle frontal gyrus. In addition, better task performance was associated with increased task-related connectivity between the posterior cingulate gyrus, middle frontal gyrus, cuneus, and hippocampus. The findings indicate that age has a negative effect on white matter microstructure, which in turn has a negative impact on memory performance. However, fornix mi...Continue Reading

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Citations

Jun 29, 2018·Human Brain Mapping·Vincent PozorskiCatherine L Gallagher
Jan 9, 2019·Journal of Pineal Research·Antje JilgJörg H Stehle
Mar 29, 2020·Brain and Neuroscience Advances·Bethany M CoadClaudia Metzler-Baddeley
Jun 23, 2020·Brain Connectivity·Susan L BenearIngrid R Olson
Apr 9, 2020·Frontiers in Aging Neuroscience·Dayana HayekDaria Antonenko
Oct 26, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Dana KanelChiara Nosarti
Apr 9, 2021·Developmental Neurobiology·Preeti KarCatherine Lebel
May 20, 2021·Brain Communications·Margot Juliëtte OvermanSamrah Ahmed
Apr 9, 2019·NeuroImage·Jess E ReynoldsCatherine Lebel
Aug 1, 2021·Neurobiology of Aging·Jenna L MerensteinIlana J Bennett

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