Fornix Structural Connectivity and Allostatic Load: Empirical Evidence From Schizophrenia Patients and Healthy Controls

Psychosomatic Medicine
Anya SavranskyL Elliot Hong

Abstract

The fornix is a white matter tract carrying the fibers connecting the hippocampus and the hypothalamus, two essential stress-regulatory structures of the brain. We tested the hypothesis that allostatic load (AL), derived from a battery of peripheral biomarkers indexing the cumulative effects of stress, is associated with abnormalities in brain white matter microstructure, especially the fornix, and that higher AL may help explain the white matter abnormalities in schizophrenia. Using 13 predefined biomarkers, we tested AL in 44 schizophrenic patients and 33 healthy controls. Diffusion tensor imaging was used to obtain fractional anisotropy (FA) values of the fornix and other white matter tracts. AL scores were significantly elevated in patients compared with controls (F(3,77) = 7.87, p = .006). AL was significantly and inversely correlated with FA of fornix in both controls (r = -.58, p = .001) and patients (r = -.36, p = .023). Several nominally significant (p < .05 but did not survive Bonferroni correction for multiple comparison) correlations were also observed between AL and FA of other white matter tracts in schizophrenic patients. However, the fornix was the only tract exhibiting a correlation with AL in both groups. Thes...Continue Reading

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Citations

Jan 30, 2018·Frontiers in Human Neuroscience·Jonatan Ottino-GonzálezMaite Garolera
Oct 12, 2019·Schizophrenia Bulletin·Yan-Fang ZhouL Elliot Hong
Jun 23, 2020·Brain Connectivity·Susan L BenearIngrid R Olson
Nov 14, 2018·Translational Psychiatry·Anya SavranskyL Elliot Hong
Oct 28, 2018·Scientific Reports·J Ottino-GonzálezM Garolera
Jul 3, 2019·Schizophrenia Research·Patryk PiotrowskiBłażej Misiak
Mar 5, 2021·Journal of Psychiatric Research·Anya SavranskyL Elliot Hong
Aug 18, 2020·Psychotherapy and Psychosomatics·Jenny GuidiGiovanni A Fava
Jul 3, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric L GoldwaserL Elliot Hong

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