Forskolin: genotoxicity assessment in Allium cepa

Mutation Research. Genetic Toxicology and Environmental Mutagenesis
Khalid Pasha MohammedParveen Jahan

Abstract

Forskolin, a diterpene, 7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one (C22H34O7) isolated from Coleus forskohlii, exerts multiple physiological effects by stimulating the enzyme adenylate cyclase and increasing cyclic adenosine monophosphate (cAMP) concentrations. Forskolin is used in the treatment of hypertension, congestive heart failure, eczema, and other diseases. A cytogenetic assay was performed in Allium cepa to assess possible genotoxic effects of forskolin. Forskolin was tested at concentrations 5-100 μM for exposure periods of 24 or 48 h. Treated samples showed significant reductions in mitotic index (p < 0.05) and increases in the frequency of chromosome aberrations (p < 0.01) at both exposure times. The treated meristems showed chromosome aberrations including sticky metaphases, sticky anaphases, laggard, anaphase bridges, micronuclei, polyploidy, fragments, breaks, and C-mitosis. Forskolin may cause genotoxic effects and further toxicological evaluations should be conducted to ensure its safety.

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Citations

Aug 16, 2016·Ecotoxicology and Environmental Safety·Marcel José PalmieriLisete Chamma Davide
Mar 13, 2017·Environmental Monitoring and Assessment·Sonam Verma, Alka Srivastava
May 16, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ya-Ping ZhangYao-Bin Zhu
Jul 30, 2021·Environmental Monitoring and Assessment·Farhana MasoodRavinder Kumar Kohli

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