Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depression

Biological Psychiatry
J A Menninger, B Tabakoff

Abstract

We investigated platelet adenylyl cyclase activity in 17 subjects with a history of major depression ("depressed subjects") and 20 controls. Forskolin was used to directly activate adenylyl cyclase, while guanine nucleotides (Gpp(NH)p) and fluoride ions were used to measure adenylyl cyclase activity modulated through the G proteins. Forskolin-stimulated adenylyl cyclase was significantly lower in the depressed subjects (p < 0.0005). There was a statistically significant difference in basal adenylyl cyclase activity between male depressed subjects and male controls. The basal adenylyl cyclase activity was also lower in female depressed subjects, but this difference did not reach statistical significance (p < 0.2). The adenylyl cyclase activity measured after stimulation with a guanine nucleotide or cesium fluoride did not differ between control and depressed male or female subjects. Severity of current depression and the current use of antidepressant medication were not related to the lower forskolin-stimulated enzyme activity in the depressed subjects. The difference in forskolin-stimulated adenylyl cyclase activity appears to reflect a qualitative difference in the adenylyl cyclase enzyme activity in persons with a history of ...Continue Reading

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Citations

Sep 3, 1998·Alcoholism, Clinical and Experimental Research·H IkedaB Tabakoff
Jan 12, 1999·Alcoholism, Clinical and Experimental Research·J A MenningerB Tabakoff
Aug 10, 2002·Alcoholism, Clinical and Experimental Research·Paula L HoffmanUNKNOWN WHO/ISBRA Study on State andTrait Markers of Alcohol Use and Dependence Investigators
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May 13, 2021·Depression Research and Treatment·Ali HosseinzadehHossein Amini-Khoei
Oct 27, 2021·Physiological Reviews·Katrina F OstromRennolds S Ostrom

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