Forty years of translational cancer research

Cancer Discovery
William N Hait

Abstract

Forty years after the signing of the National Cancer Act, we have produced a stunning repository of scientific information that is being translated into better therapies for patients. Although challenges remain, many solutions have been adopted, leading to early signs of progress against some of humankind's most dreadful diseases. This Prospective attempts to highlight some of the approaches that have been successful and analyze some that have not, and peers into a future in which renewal of the investment in cancer research will produce further benefits for patients.

References

Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P B Schiff, S B Horwitz
Sep 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·S E BarrieM Jarman
May 24, 2001·Clinical Pharmacology and Therapeutics·J A Dimasi
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cai-Hong YunMichael J Eck
Jul 4, 2008·The New England Journal of Medicine·Shyamala MaheswaranDaniel A Haber
Jul 23, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerhardt AttardJohann S de Bono
Jan 20, 2009·Clinical Pharmacology and Therapeutics·R H Glassman, M J Ratain
Feb 12, 2009·Cancer Research·William N Hait, Trevor W Hambley
Feb 12, 2009·Cancer Research·Trevor W Hambley, William N Hait
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Apr 20, 2010·Lancet·Howard I ScherUNKNOWN Prostate Cancer Foundation/Department of Defense Prostate Cancer Clinical Trials Consortium
May 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Samir N KhleifUNKNOWN AACR-FDA-NCI Cancer Biomarkers Collaborative
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Sep 8, 2010·The New England Journal of Medicine·Keith T FlahertyPaul B Chapman
Oct 29, 2010·The New England Journal of Medicine·Eunice L KwakA John Iafrate
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 27, 2011·The New England Journal of Medicine·Johann S de BonoUNKNOWN COU-AA-301 Investigators
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok

❮ Previous
Next ❯

Citations

Jan 14, 2012·Expert Opinion on Therapeutic Targets·William C S Cho
Nov 3, 2016·Nature Reviews. Clinical Oncology·James P B O'ConnorJohn C Waterton
Apr 29, 2015·World Medical & Health Policy·Shannon GibsonTrudo Lemmens
Sep 15, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lewis C CantleyPatricia S Steeg
Nov 6, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Debashis SarkerJohann S de Bono
Mar 26, 2021·Nature Reviews. Clinical Oncology·Abhijit PalJohann de Bono

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.