Fos activation patterns related to acute ethanol and conditioned taste aversion in adolescent and adult rats

Alcohol
Jessica Saalfield, Linda P Spear

Abstract

Studies in rats have revealed marked age differences in sensitivity to the aversive properties of ethanol, with a developmental insensitivity to ethanol aversion that is most pronounced during pre- and early adolescence, declining thereafter to reach the enhanced aversive sensitivity of adults. The adolescent brain undergoes significant transitions throughout adolescence, including in regions linked with drug reward and aversion; however, it is unknown how ontogenetic changes within this reward/aversion circuitry contribute to developmental differences in aversive sensitivity. The current study examined early adolescent (postnatal day [P]28-30) and adult (P72-74) Sprague-Dawley male rats for conditioned taste aversion (CTA) after doses of 0, 1.0, or 2.5 g/kg ethanol, and patterns of neuronal activation in response to ethanol using Fos-like immunohistochemistry (Fos+) to uncover regions where age differences in activation are associated with ethanol aversion. An adolescent-specific ethanol-induced increase in Fos+ staining was seen within the nucleus accumbens shell and core. An age difference was also noted within the Edinger-Westphal nucleus (EW) following administration of the lower dose of ethanol, with 1 g/kg ethanol produc...Continue Reading

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Citations

Feb 19, 2020·Alcoholism, Clinical and Experimental Research·Justine D LandinDavid F Werner
Nov 30, 2019·The European Journal of Neuroscience·Emily C WrightBrian C Trainor
Aug 14, 2019·Alcoholism, Clinical and Experimental Research·Samuel W CentanniDanny G Winder
Apr 17, 2020·Frontiers in Behavioral Neuroscience·Trevor T Towner, Elena I Varlinskaya

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