Fos-expressing neuronal ensemble in rat ventromedial prefrontal cortex encodes cocaine seeking but not food seeking in rats.

Addiction Biology
Louisa KaneBrandon L Warren

Abstract

Neuronal ensembles in ventromedial prefrontal cortex (vmPFC) play a role in both cocaine and palatable food seeking. However, it is unknown whether similar or different vmPFC neuronal ensembles mediate food and cocaine seeking. Here, we used the Daun02 inactivation procedure to assess whether the neuronal ensembles mediating food and cocaine seeking can be functionally distinguished. We trained male and female Fos-LacZ rats to self-administer palatable food pellets and cocaine on alternating days for 18 days. We then exposed the rats to a brief nonreinforced food- or cocaine-seeking test to induce Fos and β-gal in neuronal ensembles associated with food or cocaine seeking, respectively and infused Daun02 into vmPFC to ablate the β-gal-expressing ensembles. Two days later, we tested the rats for food or cocaine seeking under extinction conditions. Although inactivation of the food-seeking ensemble did not influence food or cocaine seeking, inactivation of the cocaine-seeking ensemble reduced cocaine seeking but not food seeking. Results indicate that the neuronal ensemble activated by cocaine seeking in vmPFC is functionally separate from the ensemble activated by food seeking.

References

Jan 1, 1988·Plastic and Reconstructive Surgery·A C MasqueletC Gerber
Aug 20, 1993·Science·M A Wilson, B L McNaughton
Nov 4, 2000·The American Journal of Psychiatry·H GaravanE A Stein
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·R CiccocioppoF Weiss
Nov 16, 2004·Neuron·John F GuzowskiEdvard I Moser
Aug 2, 2007·PloS One·Magalie LenoirSerge H Ahmed
Apr 22, 2009·Learning & Memory·Jamie PetersGregory J Quirk
Feb 22, 2011·Nature Neuroscience·Jennifer M BossertYavin Shaham
May 6, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M Otis, Devin Mueller
Mar 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·James M HymanJeremy K Seamans
Aug 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sanya FanousBruce T Hope
Oct 4, 2013·Nature Reviews. Neuroscience·Fabio C CruzBruce T Hope
Mar 8, 2014·Addiction Biology·Heather B Madsen, Serge H Ahmed
May 30, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fabio C CruzBruce T Hope
Apr 10, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·F Javier RubioBruce T Hope
Aug 1, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simone PfarrWolfgang H Sommer
Jun 24, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brandon L WarrenBruce T Hope
Aug 19, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Douglas FunkA D Lê
Jan 27, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniele CaprioliYavin Shaham
Aug 6, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leslie R WhitakerBruce T Hope
Jul 25, 2019·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brandon L WarrenBruce T Hope

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Citations

Sep 29, 2020·Molecular Psychiatry·Ana-Clara BobadillaPeter W Kalivas
Jun 25, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rajtarun MadangopalBruce T Hope

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