Fos-immunoreactive responses in inferior colliculi of rats with experimental audiogenic seizure susceptibility

Epilepsy Research
J Kwon, M Pierson

Abstract

Audiogenic seizure (AGS) susceptibility is a reflex epilepsy of rodents in which acoustic stimulation evokes wild running attacks and subsequent convulsions. Susceptibility can be induced in non-susceptible strains by treatments causing transient or permanent hearing losses as long as these occur during the neonatal period. The defect which is the basis of susceptibility has been proposed to be a failure of developmental organization of inferior colliculus (IC) into frequency selective zones. That is, high frequency stimuli evoke responses in broader arrays of neurons in ICs of susceptible rats than in those of neonatally untreated (non-susceptible) controls. Nonetheless, this observation has been made only in rats in which susceptibility was induced by exposure to intense noise on postnatal day (PND) 14. By contrast, the present study examines whether unusually broad topographic responses are also characteristic in ICs of rats made susceptible by the neonatal administration of low doses of the ototoxic antibiotic, kanamycin (KM). Patterns of Fos-like immunoreactivity (Foslir) induced by seizures or pure tone stimuli were compared in ICs of adult Wistar rats which neonatally had been (a) sham-treated; (b) noise-exposed on PND 1...Continue Reading

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Citations

Jun 29, 2005·Brain Research Bulletin·Xianchun LiYinghe Hu
Aug 15, 2000·Neuroscience and Biobehavioral Reviews·K C Ross, J R Coleman
Jul 22, 1998·Progress in Neurobiology·C L FaingoldA Riaz
Apr 22, 2014·Hearing Research·Wei SunJi Li
Sep 28, 2015·Experimental Neurology·Christopher D MakinsonAndrew Escayg
Oct 5, 2011·The European Journal of Neuroscience·André FisahnBarbara Canlon
Jul 6, 2000·Experimental Neurology·J R ColemanK C Ross
Sep 3, 2005·Developmental Neuroscience·Brian D KleinH Steve White
Nov 25, 2003·Journal of Neuroscience Research·Douglas S WebberJohn Edmond

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