Fos induction and persistence, neurodegeneration, and interneuron activation in the hippocampus of epilepsy-resistant versus epilepsy-prone rats after pilocarpine-induced seizures

Hippocampus
P F FabeneM Bentivoglio

Abstract

Previous studies demonstrated that the spiny rat Proechimys guyannensis exhibits resistance to experimental epilepsy. Neural activation was studied in the Proechimys hippocampus, using Fos induction, within 24 h after pilocarpine-induced seizures; neurodegenerative events were investigated in parallel, using FluoroJade B histochemistry. These parameters were selected since pilocarpine-induced limbic epilepsy is known to elicit immediate early gene expression and cell loss in the hippocampus of seizure-prone laboratory rodents. At variance with matched experiments in Wistar rats, pilocarpine injection resulted in Proechimys in seizure episodes that, as previously reported, did not develop into status epilepticus. At 3 h and 8 h after seizure onset, Fos immunoreactivity filled the dentate gyrus of both rat species, and was quite marked in pyramidal cells of the Proechimys Ammon's horn. At 24 h, Fos immunoreactivity dropped in the Wistar hippocampus and persisted in Proechimys. At 8 h and 24 h, FluoroJade-stained neurons were very few in the Proechimys hippocampus, whereas they were abundant in that of Wistar rats. Double immunohistochemistry for Fos and parvalbumin, the protein expressed by fast-spiking hippocampal interneurons, ...Continue Reading

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Citations

Jul 1, 2005·Current Neurology and Neuroscience Reports·Sanjay M Sisodiya
Oct 15, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Jose C da SilvaArthur Cukiert
Apr 30, 2009·Brain Research·Melanie P Leussis, Stephen C Heinrichs
Jun 16, 2010·Neuroscience·C A ScorzaE A Cavalheiro
Nov 9, 2016·Behavioural Brain Research·Giovanni ProvenzanoYuri Bozzi
Feb 8, 2018·Frontiers in Behavioral Neuroscience·Marcia J Guimarães MarquesCarla A Scorza

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