PMID: 8233100Aug 20, 1993

Fos induction in brainstem neurons by intravenous hypertonic saline in the conscious rat

Neuroscience Letters
S L HochstenbachJ Ciriello


Experiments were done in conscious rats to investigate the effect of intravenous infusion of hypertonic saline on the induction of the protein Fos, in brainstem neurons. Neurons containing Fos-like immunoreactivity were observed in the caudal nucleus of the solitary tract (NTS), the caudal and rostral ventrolateral medulla, and parabrachial nucleus after an infusion of solutions containing 1.4 M NaCl. Little or no expression of Fos was detected in brainstem neurons after intravenous infusions of either physiological (143 mM) or hypotonic (106 mM) NaCl solutions. These data provide evidence for the involvement of brainstem structures in osmoregulatory functions and suggest that brainstem neuronal circuits that function in cardiovascular regulation may also be shared by those involved in body fluid homeostasis.


Dec 22, 1985·The Journal of Comparative Neurology·C A RossD J Reis
Nov 1, 1988·Experimental Neurology·M DragunowG S Robertson


Jan 1, 1996·Progress in Neurobiology·A J Lawrence, B Jarrott
Oct 15, 2008·The Journal of Comparative Neurology·Jung-Won ShinArthur D Loewy
May 30, 2013·Behavioural Brain Research·Jason M Moreau, J Ciriello
Oct 28, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joel C Geerling, Arthur D Loewy
Jan 14, 1999·The American Journal of Physiology·M P Rosas-ArellanoJ Ciriello

Related Concepts

Brain Stem
Intravenous Infusion Procedures
Pontine Structure
Saline Solution, Hypertonic
Gene Expression
Fos B Protein
FOS gene

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