Fos induction in cortical interneurons during spontaneous wakefulness of rats in a familiar or enriched environment

Brain Research Bulletin
Giuseppe BertiniMarina Bentivoglio

Abstract

It has been repeatedly reported that Fos is spontaneously induced in several brain structures, including the cerebral cortex, during wakefulness. To ascertain whether cortical interneurons are involved in this state-dependent oscillation of gene regulation, we combined Fos immunocytochemistry with immunostaining of either parvalbumin or calbindin, known markers of cortical interneurons. Immunopositive neurons were examined in the sensorimotor and cingulate cortex. In rats perfused in basal conditions, a minor proportion (around 8%) of Fos-immunoreactive neurons in the parietal cortex were also parvalbumin- or calbindin-immunoreactive; these double immunostained cells accounted for 13% of the parvalbumin- and 34% of the calbindin-labeled neurons. Colocalization of Fos with either calcium-binding protein was instead not observed in the cingulate cortex. In rats stimulated by novel environmental cues during the period of wakefulness preceding perfusion, Fos-positive neurons increased markedly relative to unstimulated animals, and involved the majority of the calbindin- or parvalbumin-labeled cell populations (60-75% and over 95%, respectively). In the neuronal populations in which Fos was induced by exposure to the enriched enviro...Continue Reading

References

Nov 1, 1989·Trends in Neurosciences·J I Morgan, T Curran
Aug 1, 1985·Experimental Neurology·D W Hoovler, J J Bernstein
Jan 1, 1995·Brain Research Bulletin·Z C PengM Bentivoglio
Aug 1, 1993·The European Journal of Neuroscience·G Grassi-ZucconiM Bentivoglio
Oct 1, 1996·Progress in Neurobiology·D G Herrera, H A Robertson
Sep 1, 1997·Cerebral Cortex·Y Kawaguchi, Y Kubota

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Citations

Nov 21, 2007·Neuroscience and Biobehavioral Reviews·Eric A StoneDavid Quartermain
Aug 27, 2013·Behavioural Brain Research·Samuel DeurveilherKazue Semba

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