Fos protein expression in mouse hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei upon osmotic stimulus: colocalization with vasopressin, oxytocin, and tyrosine hydroxylase

Neurochemistry International
Zdeno PirnikAlexander Kiss

Abstract

The quantity and topography of activated vasopressin (AVP), oxytocin (OXY), and tyrosine hydroxylase (TH) neurons were studied immunohistochemically in the anterior, middle, and posterior portions of the PVN and SON in mice 60 min after a single injection of hypertonic saline (HS, 400 microl 1.5M, i.p.). Fos-neuropeptide double-stainings revealed: (1) Fos expression in each portion of the PVN and SON; (2) maximal number of Fos-AVP (79 cells) and Fos-OXY (50 cells) double-labelings in the middle portion of the PVN; (3) low number of Fos-TH perikarya in the PVN and their lack in the SON; (4) similar incidence (around 50%) of Fos-AVP and Fos-OXY perikarya in the SON; and (5) presence of activated AVP, OXY, and TH neurons in the periventricular, subependymal, and sub-PVN zones of the PVN. Topographic analysis revealed that the majority of AVP neurons expressing Fos occupied the dorsolateral and central part of the middle portion of the PVN. In the same PVN portion, Fos-OXY neurons occurred in similar frequency, however, they were primarily distributed along the lateral and medial margins of the PVN. In the SON, Fos-OXY cells occupied mainly its dorsal, while Fos-AVP cells predominated in its ventral part. The data clearly indicate ...Continue Reading

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Citations

Nov 26, 2010·Cellular and Molecular Life Sciences : CMLS·Ming-Yi ChouPung-Pung Hwang
Mar 14, 2009·Cellular and Molecular Neurobiology·Zdeno PirnikAlexander Kiss
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jessica Y S ChuBilly K C Chow
Sep 18, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joan Y Summy-Long, Sanmei Hu
Feb 25, 2010·Endocrinology·Mayowa A OsundijiMark L Evans
Oct 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Heon-Jin LeeW Scott Young
May 11, 2011·Brain Research·Miriam Goebel-StengelYvette Taché
Apr 16, 2015·Frontiers in Systems Neuroscience·Justin A SmithEric G Krause
Apr 11, 2007·Toxicology·Nadia E García-MedinaCharles C Horn
Apr 2, 2011·Physiology & Behavior·Jaidee K ZavalaKristin L Gosselink
Jun 27, 2018·Journal of Neuroendocrinology·Toru YokoyamaYasuhito Uezono
Dec 29, 2011·Endocrinology·Ronald St-LouisHélène Hardin-Pouzet
Aug 28, 2019·Stress : the International Journal on the Biology of Stress·Eduardo Albino Trindade FortalezaFernando Morgan Aguiar Corrêa

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