Fosfomycin for the initial treatment of acute haematogenous osteomyelitis

Archives of Disease in Childhood
N CortiD Nadal

Abstract

At our institution there has been a dichotomous antimicrobial treatment behaviour for acute haematogenous osteomyelitis (AHOM) since 1984. The surgical department favoured fosfomycin as initial choice and the medical department beta lactams. We aimed to compare the performance of both strategies. Data from patients discharged with the diagnosis of AHOM between January 1984 and January 1998 were gathered from the charts by means of a questionnaire. Patients receiving fosfomycin treatment (FT) were compared with those receiving fosfomycin plus other antimicrobials (FT+) and those receiving no fosfomycin treatment (NFT). A total of 103 patients aged 0.1-15.5 years (mean 6.5, median 6.9) with AHOM received no surgical treatment initially. In 23 (22.3%) FT was instilled initially, in 47 (45.6%) FT+, and in 33 (32.0%) NFT. The pathogen was established in 30%, 36%, and 42% of FT, FT+, and NFT patients, respectively, Staphylococcus aureus being the predominant isolate. Mean C reactive protein levels and erythrocyte sedimentation rates normalised in all treatment groups after two and four weeks, respectively. The mean duration of intravenous antimicrobial treatment in FT patients was 2.5 weeks, in FT+ patients 3.1 weeks, and in NFT pati...Continue Reading

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Citations

Nov 17, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M PopovicC Joukhadar
Dec 10, 2013·International Journal of Antimicrobial Agents·José A LepeJavier Aznar
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew E FalagasPetros I Rafailidis
Jul 12, 2011·Clinical Pharmacokinetics·Friederike TraunmüllerChristian Joukhadar
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Nov 19, 2003·Current Opinion in Infectious Diseases·Jennifer A Shuford, James M Steckelberg
May 26, 2021·Expert Review of Anti-infective Therapy·Katerina G TsegkaMatthew E Falagas

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