Abstract
We investigated fosfomycin susceptibility in Escherichia coli clinical isolates from South Korea, including community-onset, hospital-onset, and long-term care facility (LTCF)-onset isolates. The resistance mechanisms and genotypes of fosfomycin-resistant isolates were also identified. Finally, the in vitro efficacy of combinations of fosfomycin with other antibiotics were examined in susceptible or extended spectrum β-lactamase (ESBL)-producing E. coli isolates. The fosfomycin resistance rate was 6.7% and was significantly higher in LTCF-onset isolates than community-onset and hospital-onset isolates. Twenty-one sequence types (STs) were identified among 19 fosfomycin-resistant E. coli isolates, showing diverse genotypes. fosA3 was found in only two isolates, and diverse genetic variations were identified in three genes associated with fosfomycin resistance, namely, GlpT, UhpT, and MurA. Some fosfomycin-resistant E. coli isolates carried no mutations. In vitro time-kill assays showed that fosfomycin alone did not exhibit an excellent killing activity, compared with ciprofloxacin in susceptible isolates and with ertapenem in ESBL producers. However, combining fosfomycin with cefixime or piperacillin-tazobactam eradicated suscep...Continue Reading
References
May 10, 1974·Annals of the New York Academy of Sciences·F M KahanH Kropp
Jul 13, 2002·The American Journal of Medicine·Betsy Foxman
Aug 26, 2003·Antimicrobial Agents and Chemotherapy·Annika I NilssonDan I Andersson
Mar 31, 2005·FEMS Microbiology Letters·Jungmin KimDong-Taek Cho
May 13, 2006·Molecular Microbiology·Thierry WirthMark Achtman
Feb 16, 2007·Diagnostic Microbiology and Infectious Disease·Kwan Soo KoJae-Hoon Song
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew E FalagasPetros I Rafailidis
Nov 26, 2009·The Journal of Infection·Mi Young LeeKwan Soo Ko
Jan 15, 2010·International Journal of Antimicrobial Agents·Sho TakahataKazunori Tomono
Jun 25, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James R JohnsonMariana Castanheira
Nov 19, 2011·The Journal of Antimicrobial Chemotherapy·Drosos E KarageorgopoulosMatthew E Falagas
Jan 11, 2012·Antimicrobial Agents and Chemotherapy·Jianxia HouJian-Hua Liu
Mar 2, 2012·The Journal of Biological Chemistry·Jin-Yi ZhuErnst Schönbrunn
Aug 16, 2012·The Journal of Antimicrobial Chemotherapy·So-Young LeeYoshichika Arakawa
Apr 30, 2013·Clinical Therapeutics·Sam K BouchillonStephen P Hawser
Aug 9, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aylin ColpanUNKNOWN VICTORY (Veterans Influence of Clonal Types on Resistance: Year 2011) Investigators
Aug 15, 2014·Journal of Korean Medical Science·Mi-Ran SeoHyunjoo Pai
Sep 17, 2014·International Journal of Antimicrobial Agents·Michael KreskenUNKNOWN Working Party ‘Antimicrobial Resistance’ of the Paul-Ehrlich-Society for Chemotherapy
Jun 1, 2015·International Urology and Nephrology·Yang Hyun ChoKwangsung Park
Jun 2, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C G Giske
Aug 8, 2015·PloS One·Ya LiJian Liu
Jan 27, 2016·Emerging Infectious Diseases·Ana C MendesLuísa Peixe
Mar 1, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Sangeeta Sastry, Yohei Doi
Jan 1, 2013·Antibiotics·Alfredo Castañeda-GarcíaAlexandro Rodríguez-Rojas
Jan 8, 2017·Cold Spring Harbor Perspectives in Medicine·Lynn L Silver
Oct 1, 2018·International Journal of Antimicrobial Agents·Matthew E FalagasKonstantinos Z Vardakas
Citations
Aug 14, 2020·Antibiotics·Roberta Maria AntonelloStefano Di Bella
Nov 17, 2020·Frontiers in Microbiology·Vincent CattoirFrançois Guérin
Mar 7, 2021·Pharmaceuticals·Ozioma F NwaborSarunyou Chusri
Jul 11, 2021·The Journal of Antibiotics·Cristiane Dos SantosOctávio Luiz Franco