Fosfomycin vs. quinolone-based antibiotic prophylaxis for transrectal ultrasound-guided biopsy of the prostate: a systematic review and meta-analysis

Prostate Cancer and Prostatic Diseases
Jurate NoreikaiteBhavan Prasad Rai

Abstract

Infection-related complications secondary to quinolone resistance have been on the rise following transrectal ultrasound-guided biopsy of the prostate (TRUSBP). The aim of this review was to compare the efficacy of fosfomycin with quinolone-based antibiotic prophylaxis for TRUSBP. A systematic review in line with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) and Cochrane guidelines was conducted. All studies comparing fosfomycin vs. non-fosfomycin antimicrobial prophylaxis for TRUSBP were considered. The main outcomes were number of urinary tract infections (UTIs) (overall, afebrile, febrile, and urosepsis) and fluoroqinolone resistance. Secondary outcomes were positive urine and blood cultures, and adverse effects of drugs. Five studies comparing fosfomycin and non-fosfomycin antimicrobials were included in the review. In all, 1447 and 1665 patients were included in the fosfomycin and non-fosfomycin cohorts, respectively. The systematic review report significantly lower UTIs in the fosfomycin cohort (M-H, Fixed, 95% CI), 0.20 (0.13, 0.30), p < 0.00001. Urine cultures from patients given fosfomycin showed significantly lower resistance rates (M-H, Fixed, 95% CI) 0.27 (0.15, 0.50), p < 0.0001. T...Continue Reading

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Citations

Feb 1, 2020·Expert Opinion on Pharmacotherapy·Riccardo BientinesiEmilio Sacco
Oct 13, 2020·Der Urologe. Ausg. A·A PilatzF Wagenlehner
Nov 2, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Tristan DeloryMatthieu Lafaurie
Feb 10, 2021·Der Urologe. Ausg. A·Jennifer KranzFlo Ri An Wagenlehner
Dec 7, 2018·European Urology Focus·Adrian PilatzBenjamin Pradere
May 13, 2021·Aktuelle Urologie·Florian WagenlehnerAdrian Pilatz

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Methods Mentioned

BETA
biopsies
biopsy

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