Fosinopril Prevents the Development of Tactile Allodynia in a Streptozotocin-Induced Diabetic Rat Model

Drug Development Research
Claudia I Araiza-SaldañaVinicio Granados-Soto

Abstract

The aim of this study was to evaluate fosinopril-induced changes in hemodynamic parameters and tactile allodynia in a rat model of diabetes. Diabetes was induced by streptozotocin (STZ; 50 mg/kg, i.p.) in male Wistar rats. STZ produced hyperglycemia, weight loss, polydipsia, polyphagia, and polyuria as well as long-term arterial hypotension, bradycardia, and tactile allodynia at 10-12 weeks. Daily administration of the angiotensin converting enzyme inhibitor, fosinopril (25 mg/kg, p.o., for 11 weeks) partially reduced the loss of body weight, decreased hyperglycemia, and systolic blood pressure in diabetic rats. Likewise, systemic administration of fosinopril prevented the development and maintenance of tactile allodynia in STZ-induced diabetic rats. These data suggest that fosinopril may have a role in the pharmacotherapy of diabetic neuropathic pain.

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Citations

Feb 1, 2017·Lasers in Medical Science·Igor Rafael Correia RochaMarucia Chacur
Apr 24, 2019·American Journal of Hypertension·Georgios PonirakisRayaz A Malik
Apr 30, 2020·Experimental and Therapeutic Medicine·Ziqiang XuZhigang Wu
Mar 17, 2019·International Journal of Environmental Research and Public Health·Syed Awais AttiqueMuhammad Zohaib Nawaz

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