Abstract
Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined in vitro/in silico approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Escherichia coli strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named fosM.
References
Feb 6, 2003·Cellular and Molecular Life Sciences : CMLS·K P Scott
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Sep 1, 2004·Trends in Microbiology·Abigail A SalyersYanping Wang
Sep 18, 2007·Advances in Applied Microbiology·Katarzyna A Kazimierczak, Karen P Scott
Sep 29, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Argyris S MichalopoulosVassilios Gougoutas
Sep 6, 2013·Biochemistry·Matthew K ThompsonRichard N Armstrong
Oct 23, 2013·Antimicrobial Agents and Chemotherapy·Sushim Kumar GuptaJean-Marc Rolain
Mar 20, 2014·Bioinformatics·Torsten Seemann
Nov 5, 2014·Frontiers in Microbiology·Nadim CassirPhilippe Brouqui
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
Mar 26, 2016·International Journal of Antimicrobial Agents·Konstantinos Z VardakasMatthew E Falagas
Jun 29, 2016·Journal of Global Health·Mark WoolhouseHarish Nair
Sep 19, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M De LaveleyeUNKNOWN multicenter study group
Nov 11, 2016·New Microbes and New Infections·G MourembouF Bittar
Jan 8, 2017·Cold Spring Harbor Perspectives in Medicine·Lynn L Silver
Mar 11, 2017·New Microbes and New Infections·B SenghorJ-C Lagier
Jul 15, 2017·New Microbes and New Infections·F CadoretD Raoult
Aug 31, 2017·MBio·Ryota ItoYohei Doi
Mar 1, 2019·Frontiers in Microbiology·Ziwei SongJing Li
Aug 31, 2019·Future Microbiology·Serena SimoniMarina Mingoia
Jan 15, 2020·Antimicrobial Agents and Chemotherapy·Nicolas KiefferPatrice Nordmann