Fostamatinib for the treatment of chronic immune thrombocytopenia.

Blood
Nathan T Connell, Nancy Berliner

Abstract

Fostamatinib is a spleen tyrosine kinase inhibitor recently approved for the treatment of chronic immune thrombocytopenia (ITP) in patients without adequate response to at least 1 prior line of therapy. This article reviews fostmatinib's mechanism of action and its clinical safety and efficacy in 2 industry-sponsored multicenter phase 3 randomized controlled trials in North America, Australia, and Europe (FIT1 and FIT2). Cost comparisons are discussed as well as the role of fostamatinib in relation to other options for chronic ITP.

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Citations

Mar 5, 2020·Platelets·Elizabeth J HainingSteve P Watson
Aug 27, 2019·Frontiers in Immunology·Kata P SzilveszterAttila Mócsai
Apr 3, 2021·Therapeutic Advances in Hematology·Nikki Agarwal, Ankit Mangla
Apr 4, 2021·Journal of Clinical Medicine·Sylvain Audia, Bernard Bonnotte
May 13, 2021·Science Translational Medicine·Willianne HoepelJeroen den Dunnen
Mar 11, 2021·American Journal of Physiology. Cell Physiology·Tony J ZhengJoseph E Aslan
Jan 18, 2022·Clinical and Experimental Medicine·Nagesh Kishan Panchal, Sabina Evan Prince

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