Four aged siblings with B cell chronic lymphocytic leukemia

Leukemia
F FernhoutJ J van Dongen

Abstract

All four aged siblings (>80 years) of one family presented with B cell chronic lymphocytic leukemia (B-CLL). In an attempt to find common characteristics in the four patients, we performed detailed immunological marker analysis, Southern blot analysis of immunoglobulin (Ig) genes, and cytogenetic studies. In three patients clonality of the B-cells could be proven by single Ig light chain expression, but in the fourth patient no Ig light chain expression was detected and clonality of the B cells could only be demonstrated by Southern blot analysis of the Ig genes. Interestingly, in two patients, the Ig gene rearrangement patterns were compatible with the presence of two independent B cell clones, whereas in the two other siblings a monoclonal rearrangement pattern was found. All four patients showed clonal chromosome aberrations, which were different in each patient. In the two patients with biclonal Ig gene rearrangement patterns, two unrelated clones could also be demonstrated by the cytogenetic studies. These combined Ig gene and cytogenetic data indicate the presence of two different B-CLL in two of the four patients. Remarkably, the B-CLL cells of the two oldest patients expressed the CD8 antigen, which is rarely observed. ...Continue Reading

Citations

Aug 6, 2000·British Journal of Haematology·M R YuilleR S Houlston
Sep 2, 2000·British Journal of Haematology·R S HoulstonM R Yuille
Jun 29, 2004·International Journal of Hematology·Silvana CapalboVincenzo Liso
Oct 31, 2002·American Journal of Medical Genetics·Henry T LynchWarren G Sanger
Oct 26, 2011·Leukemia & Lymphoma·Pauline Y HuangRichard I Christopherson
Jun 30, 2000·American Journal of Clinical Pathology·E D HsiR R Tubbs
Jun 1, 2002·Leukemia·R S HoulstonM R Yuille
Mar 13, 2001·American Journal of Clinical Pathology·Z KaleemM M Zutter
Sep 7, 2000·Archives of Pathology & Laboratory Medicine·A IslamJ L Ambrus

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.