PMID: 6169441Aug 1, 1981Paper

Four-base codons ACCA, ACCU and ACCC are recognized by frameshift suppressor sufJ

Cell
L Bossi, J R Roth

Abstract

The frameshift suppressor sufJ acts to correct a set of +1 frameshift mutations having very different sequences at their mutant sites. This suppressor acts by reading a 4 base codon located near, but not at, the site of each suppressible mutation. Suppression thus necessitates out-of-phase translation of the short stretch of mRNA between the site of action of the suppressor tRNA and the site of the frameshift mutation. We have identified the site read by sufJ by mutationally creating a series of such sites in the neighborhood of a previously nonsuppressible frameshift mutation. Each of the newly generated sites was formed by base substitution. Four independently generated sites were analyzed by DNA sequencing. At each site the quadruplet codon ACCX was generated (where X is A, U or C). Thus sufJ is able to read a 4 base codon in which any of three bases is acceptable in the fourth position. This is the first frameshift suppressor that does not read a run of three repeated bases in the first three positions of its codon.

References

Aug 1, 1977·Genetics·M R CulbertsonG R Fink
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W M Barnes
Feb 15, 1978·Journal of Molecular Biology·W M Barnes
Nov 25, 1978·Journal of Molecular Biology·T Kohno, J R Roth
Sep 1, 1975·Journal of Bacteriology·I InoJ Yourno
Nov 28, 1970·Journal of Molecular Biology·D L Riddle, J R Roth
May 28, 1972·Journal of Molecular Biology·D L Riddle, J R Roth
May 1, 1972·Canadian Journal of Microbiology·M L Murray, P E Hartman
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C SquiresJ Carbon
Jan 1, 1974·Annual Review of Genetics·J R Roth
Jul 1, 1968·Journal of Bacteriology·D BerkowitzB N Ames
Oct 1, 1969·Journal of Bacteriology·J YournoS Tanemura
Jun 1, 1970·Journal of Bacteriology·T KonoJ Yourno
Jun 28, 1968·Journal of Molecular Biology·S Riyasaty, J F Atkins
Nov 28, 1971·Journal of Molecular Biology·J Yourno
May 1, 1971·Journal of Bacteriology·J GreebJ C Loper
Feb 11, 1972·Science·J Yourno, T Kohno
Jun 1, 1981·Cell·J R Roth
Jul 10, 1980·Nature·L Bossi, J R Roth

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Citations

Dec 16, 2004·Angewandte Chemie·Lei Wang, Peter G Schultz
Jan 1, 1983·Molecular & General Genetics : MGG·L Bossi
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D E LevinB N Ames
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L Bossi, D M Smith
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J F Curran, M Yarus
Mar 17, 1999·The EMBO Journal·P J Farabaugh, G R Björk
May 25, 1983·Nucleic Acids Research·L Bossi, M S Ciampi
Oct 11, 1983·Nucleic Acids Research·D O Clary, D R Wolstenholme
Aug 28, 2001·Nucleic Acids Research·T HohsakaM Sisido
Dec 15, 2005·Journal of Bacteriology·Fabienne F V ChevanceKelly T Hughes
Mar 5, 2009·Microbiology and Molecular Biology Reviews : MMBR·John F Atkins, Glenn R Björk
May 13, 2006·Annual Review of Biophysics and Biomolecular Structure·Lei WangPeter G Schultz
Jan 8, 2014·Chemical Society Reviews·S A Stratmann, A M van Oijen
May 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·J Christopher AndersonPeter G Schultz
Aug 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tatsuya MaehigashiChristine M Dunham
Nov 18, 2008·Journal of Molecular Biology·S Joakim NäsvallGlenn R Björk
May 30, 2006·Journal of Molecular Biology·Sarah E Walker, Kurt Fredrick
Jan 1, 1986·Environmental Mutagenesis·P E HartmanD E Levin
Nov 12, 1981·Nature
Dec 3, 2016·Essays in Biochemistry·Leticia TorresVitor B Pinheiro
Sep 29, 2018·Proceedings of the National Academy of Sciences of the United States of America·Samuel HongChristine M Dunham
Jan 14, 2021·Nature Communications·Howard GamperYa-Ming Hou
Jan 1, 1989·Journal of Bacteriology·P BlumS Artz
Feb 1, 1989·Journal of Bacteriology·D HughesJ F Atkins
Sep 1, 1983·Microbiological Reviews·K E Sanderson, J R Roth
Nov 1, 1984·Journal of Virology·J E JanikJ A Rose
Oct 1, 1984·Molecular and Cellular Biology·R F Gaber, M R Culbertson
Oct 20, 1990·Journal of Molecular Biology·A A Richter Dahlfors, C G Kurland
Aug 1, 2021·Nature Communications·Gabriel DemoAndrei A Korostelev
Oct 1, 2021·Nature Communications·Erika A DeBenedictisAhmed H Badran

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