PMID: 2505923Oct 1, 1989Paper

Four brothers with Waldenstrom's macroglobulinemia

Cancer
G RenierD Hurez

Abstract

An exceptional family including four brothers with Waldenstrom's macroglobulinemia was studied. The four patients had different light chain IgM monoclonal components: two of the kappa type and two of the lambda type. Anti-idiotypic rabbit antisera, prepared for each monoclonal component, revealed no cross-reactivity. The four brothers did not share a common HLA A B DR haplotype and a genetic linkage to the HLA complex cannot be ascertained. Five of the 12 relatives had high serum immunoglobulin concentration (four IgG, three IgA, and two IgM) without monoclonal components. Two relatives showed auto-antibodies at low titer. Some of the youngest relatives exhibited immunological abnormalities and they may be high-risk subjects with regard to Waldenstrom's macroglobulinemia.

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Citations

Sep 24, 2008·Archives of Internal Medicine·Jill KoshiolOla Landgren
Jan 8, 2000·Hematology/oncology Clinics of North America·M A DimopoulosC Matsouka
Aug 12, 1999·Clinical and Experimental Immunology·H M OgmundsdóttirB A Agnarsson
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Aug 4, 2007·British Journal of Haematology·Rafael Fonseca, Suzanne Hayman
Feb 24, 2011·European Journal of Haematology·Hlíf SteingrímsdóttirHelga M Ogmundsdóttir
Apr 2, 2011·Clinical Lymphoma, Myeloma & Leukemia·Christina HanzisSteven P Treon
Apr 2, 2011·Clinical Lymphoma, Myeloma & Leukemia·Henry T LynchStephan Thomé
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Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mary L McMasterMargaret A Tucker

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