Four cases of mucous membrane pemphigoid with clinical features of oral lichen planus

International Journal of Dermatology
Aoi FukudaTakashi Hashimoto

Abstract

Mucous membrane pemphigoid (MMP) and oral lichen planus (OLP) show similar clinical features on the oral mucosa. As clinical manifestations of oral mucosal lesions, MMP shows blisters and erosions, whereas OLP shows lace-like whitish lesions in an annular arrangement with erythema and erosions. Histopathologically, MMP shows subepithelial bullae with infiltrates of lymphocytes and neutrophils, whereas OLP shows band-like interface infiltration of lymphocytes with damage in basal cells. However, these two diseases are frequently difficult to distinguish both clinically and histopathologically. We report four patients with oral MMP who showed OLP-like clinical and histopathological lesions. We performed direct immunofluorescence, indirect immunofluorescence of normal human skin and 1 m NaCl-split skin, enzyme-linked immunosorbent assays for BP180, BP230, and desmogleins 1 and 3, and immunoblotting of normal human epidermal and dermal extracts, recombinant proteins of BP180-NC16a and -C-terminal domains, concentrated culture supernatant of HaCaT cells, and purified laminin-332. The results of various immunological studies suggested the diagnoses of various types of MMP for all four patients. Because MMP and OLP require different t...Continue Reading

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Citations

Jun 20, 2017·International Journal of Dermatology·Muhammed Razmi TSanjeev Handa
Jun 10, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Richard WaltonMarco Carrozzo
Jul 18, 2019·American Journal of Clinical Dermatology·Hanan RashidBarbara Horváth
Sep 2, 2020·European Journal of Oral Sciences·Olav SchreursKarl Schenck
Jul 4, 2017·Proceedings·Sheevam ShahPalak Parekh
Feb 6, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·M BenzaquenL Borradori

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