Abstract
Mucous membrane pemphigoid (MMP) and oral lichen planus (OLP) show similar clinical features on the oral mucosa. As clinical manifestations of oral mucosal lesions, MMP shows blisters and erosions, whereas OLP shows lace-like whitish lesions in an annular arrangement with erythema and erosions. Histopathologically, MMP shows subepithelial bullae with infiltrates of lymphocytes and neutrophils, whereas OLP shows band-like interface infiltration of lymphocytes with damage in basal cells. However, these two diseases are frequently difficult to distinguish both clinically and histopathologically. We report four patients with oral MMP who showed OLP-like clinical and histopathological lesions. We performed direct immunofluorescence, indirect immunofluorescence of normal human skin and 1 m NaCl-split skin, enzyme-linked immunosorbent assays for BP180, BP230, and desmogleins 1 and 3, and immunoblotting of normal human epidermal and dermal extracts, recombinant proteins of BP180-NC16a and -C-terminal domains, concentrated culture supernatant of HaCaT cells, and purified laminin-332. The results of various immunological studies suggested the diagnoses of various types of MMP for all four patients. Because MMP and OLP require different t...Continue Reading
References
Jan 1, 1992·Advances in Experimental Medicine and Biology·J Mestecky, J R McGhee
Feb 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J V Bagán-SebastiánY Jiménez
Aug 1, 1989·Scandinavian Journal of Dental Research·P JungellM Malmström
Oct 1, 1989·The Journal of Clinical Investigation·T SugiT Nishikawa
Feb 1, 1984·The Journal of Investigative Dermatology·W R GammonC E Wheeler
Aug 1, 1996·Archives of Dermatological Research·K MatsumuraT Hashimoto
Feb 11, 1998·The Journal of Investigative Dermatology·L S ChanK B Gordon
Jan 29, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·M TsunenagaT Nishiyama
Feb 16, 1999·The Journal of Investigative Dermatology·Z Nie, T Hashimoto
Jun 5, 1999·Journal of Immunological Methods·S AmanoR E Burgeson
Dec 3, 1999·The British Journal of Dermatology·M YomadaT Hashimato
Feb 15, 2000·Clinical and Experimental Dermatology·A V EvansR J Hay
Oct 29, 2000·The Journal of Dermatology·M BhattacharyaB Kumar
Dec 16, 2000·The American Journal of Surgical Pathology·S C AbrahamT T Wu
Jun 19, 2001·Lancet·C A EganK B Yancey
Mar 21, 2002·Archives of Dermatology·Lawrence S ChanJohn J Zone
Nov 22, 2002·Journal of Dermatological Science·Masakazu KobayashiTakeji Nishikawa
Oct 29, 2003·Journal of Dermatological Science·Yoshiko HisamatsuTakashi Hashimoto
Nov 26, 2004·Journal of Periodontology·Marco CarrozzoSergio Gandolfo
Dec 21, 2005·Journal of Dermatological Science·Mariko YoshidaTakashi Hashimoto
Jul 20, 2007·Journal of Oral Science·Sumairi B IsmailRosnah B Zain
Mar 28, 2008·The British Journal of Dermatology·N IshiiT Hashimoto
Aug 25, 2009·Journal of the American Academy of Dermatology·Christian RoseIakov Shimanovich
Jun 25, 2010·Australian Dental Journal·A A TalackoM J Aldred
Oct 7, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M R RoopashreeAbhilasha Shukla
Mar 8, 2011·Journal of Dermatological Science·Daisuke TsurutaJonathan C R Jones
Jul 26, 2011·Journal of Signal Transduction·Pierre H Vachon
Dec 15, 2012·Lancet·Enno Schmidt, Detlef Zillikens
Mar 29, 2014·Acta Dermato-venereologica·Shu SasaiTakashi Hashimoto
Citations
Jun 20, 2017·International Journal of Dermatology·Muhammed Razmi TSanjeev Handa
May 31, 2017·International Journal of Dermatology·Roxanne BavarianMichele D Mignogna
Apr 21, 2020·Clinical and Experimental Dermatology·X Bosch-AmateP Iranzo-Fernández
Jun 10, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Richard WaltonMarco Carrozzo
Jul 18, 2019·American Journal of Clinical Dermatology·Hanan RashidBarbara Horváth
Sep 2, 2020·European Journal of Oral Sciences·Olav SchreursKarl Schenck
Jul 4, 2017·Proceedings·Sheevam ShahPalak Parekh
Feb 6, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·M BenzaquenL Borradori