PMID: 11897852Mar 19, 2002Paper

Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat

The Journal of Physiology
Steven A Prescott, Yves De Koninck

Abstract

Lamina I of the spinal dorsal horn plays an important role in the processing and relay of nociceptive information. Signal processing depends, in part, on neuronal membrane properties. Intrinsic membrane properties of lamina I neurons were therefore investigated using whole cell patch clamp recordings in a slice preparation of adult rat spinal cord. Based on responses to somatic current injection, four cell types were identified: tonic, which fire comparatively slowly but continuously throughout stimulation; phasic, which fire a high frequency burst of variable duration; delayed onset, which fire irregularly and with a marked delay to the first spike; and single spike, which typically fire only one action potential even when strongly depolarised. Classification by spiking pattern was further refined by identification of characteristic stimulus-response curves and quantification of several response parameters. Objectivity of the classification was confirmed by cluster analysis. Responses to stimulus trains and synaptic input as well as the kinetics of spontaneous synaptic events revealed differences in the signal processing characteristics of the cell types: tonic and delayed onset cells appeared to act predominantly as integrato...Continue Reading

References

Mar 1, 1990·Trends in Neurosciences·B W Connors, M J Gutnick
Apr 1, 1991·The Journal of Membrane Biology·P H Barry, J W Lynch
Jan 1, 1989·Neuroscience·A J Todd, J McKenzie
Jul 1, 1989·Journal of Neurophysiology·M Yoshimura, T M Jessell
May 22, 1986·The Journal of Comparative Neurology·J L HyldenG J Bennett
Feb 1, 1986·The Journal of Comparative Neurology·D Lima, A Coimbra
Aug 1, 1985·The Journal of Physiology·A D Craig, K D Kniffki
Mar 1, 1970·Journal of Neurophysiology·B N Christensen, E R Perl
Feb 1, 1971·The Journal of Physiology·J A Connor, C F Stevens
Dec 10, 1983·The Journal of Comparative Neurology·C J Woolf, M Fitzgerald
Feb 1, 1995·Biochemical Society Transactions·R A Calvert
Apr 1, 1996·Trends in Neurosciences·P KönigW Singer
Apr 15, 1996·The Journal of Comparative Neurology·E T ZhangA D Craig
Dec 1, 1996·Current Biology : CB·B W Connors, W G Regehr
Jan 15, 1997·Annals of the New York Academy of Sciences·S E BrauthW S Hall
Jun 2, 1998·Nature·H Agmon-SnirJ Rinzel
Nov 21, 1998·The European Journal of Neuroscience·H U DodtW Zieglgänsberger
Feb 9, 1999·Neural Computation·T K Horiuchi, C Koch
Apr 9, 1999·Nature Neuroscience·Z S HanA D Craig
Mar 18, 2000·Journal of Neuroscience Methods·N ChéryY de Koninck
Apr 12, 2000·Journal of Neurophysiology·H BesterJ F Bernard
Dec 1, 2000·Progress in Brain Research·A D Craig

❮ Previous
Next ❯

Citations

Feb 16, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·E K StaufferR M Reinking
Dec 29, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·E K StaufferD G Stuart
Jan 24, 2007·Journal of Computational Neuroscience·Bart SautoisAlan Roberts
Nov 12, 2010·Nature Reviews. Neuroscience·Andrew J Todd
Mar 4, 2010·Fiziologiia cheloveka·L V Filippova, A D Nozdrachev
Jul 15, 2005·Journal of Neurophysiology·Kimberly J DoughertyShawn Hochman
Nov 5, 2010·Journal of Neurophysiology·J F M van Brederode, A J Berger
Feb 18, 2012·Journal of Neurophysiology·Jie Li, Mark L Baccei
May 16, 2008·Journal of Neurophysiology·Kimberly J Dougherty, Shawn Hochman
Feb 3, 2012·Physiological Reviews·Hanns Ulrich ZeilhoferGonzalo E Yévenes
Oct 11, 2008·PLoS Computational Biology·Steven A PrescottTerrence J Sejnowski
Jun 30, 2010·PLoS Computational Biology·Yan GaiJohn Rinzel
Jul 27, 2011·PloS One·Javier Nogueira, Ángel Ariel Caputi
Jul 9, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rachel GrashowEve Marder
Jan 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kimberly J Dougherty, Ole Kiehn
Jan 18, 2014·Biological cybernetics·Congmin LiuShenquan Liu
Dec 19, 2013·ISRN Neurology·Pablo R Brumovsky
May 15, 2013·Discrete and Continuous Dynamical Systems. Series a·Xiangying MengJohn Rinzel
Feb 10, 2016·Frontiers in Neuroanatomy·Natalia MerkulyevaPavel Musienko
Mar 3, 2007·The Journal of Physiology·Sónia F A SantosBoris V Safronov
Nov 16, 2011·The Journal of Physiology·Chang-Hee KimSang Jeong Kim
Aug 11, 2007·The Journal of Physiology·B A GrahamR J Callister
Feb 10, 2007·The Journal of Physiology·Renée D TheissC J Heckman
Dec 25, 2003·The Journal of Physiology·Ruth RuscheweyhJürgen Sandkühler
Jul 27, 2011·The Journal of Physiology·Haijun Zhang, Patrick M Dougherty
Jul 6, 2004·The Journal of Physiology·Igor V MelnickBoris V Safronov
Mar 14, 2012·Current Opinion in Neurobiology·Steven A Prescott, Stéphanie Ratté
May 8, 2007·Neuroscience Letters·Gerardo Rojas-PiloniMiguel Condés-Lara
Dec 30, 2006·Peptides·Peter A SmithBradley K Taylor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.