Four-dimensional stereotactic radiotherapy for early stage non-small cell lung cancer: a comparative planning study

Technology in Cancer Research & Treatment
J-B PrevostJ J Nuyttens

Abstract

In this study we sought to assess the potential of the respiratory tumor tracking system of the CyberKnife to administer 3 fractions of 15 Gy in the treatment of early stage non-small cell lung cancer (NSCLC). The CyberKnife plans were compared to those developed for 3-D conformal radiotherapy (3-D CRT) administering 20 fractions of 3 Gy based on a slow CT. Ten patients with stage I NSCLC, who were previously treated with 3-D CRT, were re-planned with the CyberKnife treatment planning system. In the 3-D CRT plan, the planning target volume (PTV) included the gross tumor volume (GTV)(slow) and a 15-mm margin, whereas in the CyberKnife plan the margin was 8 mm. The physical doses from both treatment plans were converted to normalized total doses (NTD) using the linear quadratic model with an alpha/beta(tumor) of 10 Gy and alpha/beta(organs at risk (OAR)) of 3 Gy. The average minimal and mean doses administered to the PTV with the CyberKnife and 3-D CRT were 93 and 115.8 Gy and 61 and 66 Gy, respectively (p<0.0001). The mean V(20) of the CyberKnife and 3-D CRT plans were 8.2% and 6.8%, respectively (p=0.124). Both plans complied with the OAR constraints. In conclusion, 4-dimensional stereotactic radiotherapy can increase the minim...Continue Reading

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Citations

Jan 24, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joost J NuyttensMischa S Hoogeman
Sep 8, 2010·Technology in Cancer Research & Treatment·C LouisE Lartigau
Jun 18, 2015·Cancers·Kylie H KangSimon S Lo
Sep 19, 2017·Acta Oncologica·Michael FrelinghuysenJoost Jan Nuyttens
Dec 4, 2012·Physics in Medicine and Biology·Huagang YanWu Liu
Nov 3, 2012·Expert Review of Medical Devices·Joost Jan Nuyttens, Marjan van de Pol

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