Four highly oxygenated isopimarane-type diterpenes of Orthosiphon stamineus

Planta medica
Suresh AwaleShigetoshi Kadota

Abstract

Four highly oxygenated isopimarane-type diterpenes, named orthosiphols O, P and Q and nororthosiphonolide A, have been isolated from the aerial parts of Orthosiphon stamineus from Myanmar, together with three known diterpenes, orthosiphols D and E and orthosiphonone A. Their structures were determined on the basis of extensive spectral analysis. All the isolated compounds displayed mild antiproliferative activities against highly liver metastatic colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cell lines.

Citations

Dec 7, 2002·Bioorganic & Medicinal Chemistry Letters·Suresh AwaleShigetoshi Kadota
Oct 28, 2009·Journal of Medicinal Food·Mun Fei YamRusliza Basir
Aug 1, 2012·Journal of Medicinal Food·Omar Z AmeerMun Fei Yam
Sep 11, 2012·Journal of Plant Physiology·Hisashi Kato-NoguchiKiyotake Suenaga
Jan 15, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Siddig Ibrahim AbdelwahabKhalid M Alkharfy
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mun Fei YamMohd Zaini Asmawi
Mar 1, 2003·Journal of Natural Products·Suresh AwaleShigetoshi Kadota
Aug 14, 2020·Journal of Agricultural and Food Chemistry·Wei-Di ChenXiao-Dong Luo

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