Four isoforms of the signal-transduction and RNA-binding protein QKI expressed during chicken spermatogenesis

Molecular Reproduction and Development
J MezquitaC Mezquita

Abstract

Genes expressed during spermatogenesis undergo alternative initiation and alternative splicing and may be under the control of a coordinated mechanism of RNA processing. A family of proteins that combine features of signal-transduction and RNA-binding molecules could be instrumental in this process. We have characterized a cDNA from adult chicken testis that codifies a highly conserved member of the STAR protein family, the orthologue of the mouse quaking gene qki. The predicted chicken protein differs only in four amino acids from the corresponding mouse protein. Messages of 7, 6, and 5 kb are expressed differentially during chicken spermatogenesis. The 5-kb message, the predominant form in adult testis, presents heterogeneity in the coding region, showing insertions of 51 and 75 bp and a deletion of 24 bp, which gives rise to four possible isoforms of the protein.

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Aug 1, 1971·Biology of Reproduction·W I BennettR L Sidman
Apr 28, 1994·Nature·S FumagalliS A Courtneidge
Apr 1, 1995·Molecular and Cellular Biology·K Nandabalan, G S Roeder
Mar 11, 1993·Nucleic Acids Research·H SiomiG Dreyfuss

❮ Previous
Next ❯

Citations

Dec 4, 2003·Biochimica Et Biophysica Acta·Kiven E Lukong, Stéphane Richard
Nov 30, 2013·International Journal of Molecular Sciences·Flora Sánchez-Jiménez, Víctor Sánchez-Margalet
Sep 9, 2005·DNA Sequence : the Journal of DNA Sequencing and Mapping·Tomoaki MurataYasuho Taura
Apr 7, 2005·Journal of Molecular Biology·Mahon L MaguireR William Broadhurst
Sep 6, 2007·Journal of Neuroscience Research·Carol Anne Chénard, Stéphane Richard
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh
Dec 7, 2002·Neuron·Daniel LarocqueStéphane Richard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.