Four-microRNA signature for detection of type 2 diabetes

World Journal of Clinical Cases
Li-Na YanZi-Ling Li

Abstract

Sensitive, novel, and accurate biomarkers for the detection of physiological changes in type 2 diabetes (T2DM) at an early stage are urgently needed. To build a multi-parameter diagnostic model for the early detection of T2DM. MiR-148b, miR-223, miR-130a, and miR-19a levels were detected by real-time polymerase chain reaction in serum of healthy controls, individuals with impaired glucose regulation, and T2DM patients. The diagnostic value of miR-148b, miR-223, miR-130a, and miR-19a, alone or in combination, was analyzed. The area under the curve (AUC) of miR-223, which had the best diagnostic value for discriminating the impaired glucose regulation and T2DM groups, was 0.84, and the sensitivity and specificity were 73.37% and 81.37%, respectively. The AUC of the four-miRNA signature was 0.90, and the sensitivity and specificity were 78.82% and 88.23%, respectively. In the validation set, the AUC was 0.88, and the sensitivity and specificity were 78.36% and 87.63%, respectively. In summary, we have built a multi-parameter diagnostic model consisting of miR-148b, miR-223, miR-130a, and miR-19a for the detection of T2DM. It may be a potential tool for the early detection of T2DM.

References

Jan 22, 2002·The Journal of Cardiovascular Nursing·Barbara FletcherCindy Lamendola
Aug 17, 2004·The Medical Clinics of North America·Ralph A DeFronzo
Jul 15, 2011·American Journal of Hypertension·Wei-Hua WuYuan-Jian Li
Mar 25, 2014·Biochimica Et Biophysica Acta·Fatiha TaïbiLaurent Metzinger
Sep 6, 2014·Current Pharmaceutical Biotechnology·Yusuf Tutar
Feb 1, 2015·Gene·Ismail Dogu KilicH Eren Bostancı
Apr 26, 2015·Diabetes & Metabolism·C Guay, R Regazzi
May 23, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Meng YeZhongwei Lv
Nov 3, 2016·Journal of Diabetes Investigation·Lili YangJiancheng Dong
May 11, 2017·Biochimie·Joyita BanerjeeNeetu Mishra
Feb 27, 2018·Cardiovascular Diabetology·Marco WitkowskiUrsula Rauch
May 14, 2018·Advances in Experimental Medicine and Biology·Oleta A SandifordPranela Rameshwar
Jun 1, 2018·International Journal of Endocrinology·Giuseppina CatanzaroElisabetta Ferretti
Sep 27, 2018·Scientific Reports·Andrea JaegerArnold von Eckardstein
Sep 27, 2018·Metabolism: Clinical and Experimental·Habib YaribeygiAmirhossein Sahebkar
Dec 22, 2019·Current Diabetes Reports·Abigail Kennedy Grant, Lauren Golden

❮ Previous
Next ❯

Citations

Apr 4, 2021·International Journal of Molecular Sciences·Hsiuying Wang
Feb 21, 2021·The Journal of Clinical Endocrinology and Metabolism·Ya-Ke LuYu-Xiang Yan

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

Solexa

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.