Four new C20 -diterpenoid alkaloids from Aconitum rotundifolium

Journal of Asian Natural Products Research
Jifa ZhangXianli Zhou

Abstract

Four new C20-diterpenoid alkaloids, rotundifosines D-G (1-4), along with eight known ones (5-12) were isolated from the whole plant of Aconitum rotundifolium Kar. & Kir. The structures of the compounds were elucidated on the basis of spectroscopic analyses, including HR-ESI-MS and 1D, 2D NMR. Rotundifosine F (3) is a rare C20-diterpenoid alkaloid with quaternary ammonium salt. Alkaloids 1-4, 5, 6, 9, and 12 were evaluated for cytotoxicity against MCF-7, HCT-116 and HepG2 human cancer cell lines.

References

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Jun 2, 2017·Journal of Asian Natural Products Research·Lian-Hai ShanXian-Li Zhou

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Methods Mentioned

BETA
NMR
column chromatography
Assay

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