PMID: 11324754Apr 28, 2001Paper

Four new inverted terminal repeat sequences from bovine adenoviruses reveal striking differences in the length and content of the ITRs

Virus Genes
Adám L DánM Benkö

Abstract

The inverted terminal repeat (ITR) of the genome of four bovine adenovirus (BAdV) types have been sequenced, analysed and compared to the ITRs of other adenoviruses. The length of ITRs of the examined BAdVs ranged between 59 and 368 base pairs, thus the presently known longest adenovirus ITR sequence is from BAdV-10. The conserved motifs and characteristic sequence elements of the ITRs providing different binding sites for replicative proteins of viral and cellular origin seemed to be distributed according to the proposed genus classification of BAdVs. The ITRs of BAdV-10 share similarity with the members of the genus Mastadenovirus, while the ITRs of the other three sequenced serotypes (BAdV-4, 5 and strain Rus) which are candidate members of the genus Atadenovirus are very short and contain NFI and Sp1 binding sites only. The analysis of the new ITRs implied that the nucleotide sequence of the so-called core origin is highly preserved within the mastadenovirus genus only.

Citations

May 23, 2015·Virology Journal·Thanh H NguyenMark J van Raaij
Nov 14, 2006·The Journal of General Virology·Li Xing, Suresh Kumar Tikoo

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