Four peptides decrease human colon adenocarcinoma cell number and DNA synthesis via cyclic GMP.

International Journal of Gastrointestinal Cancer
William R GowerD L Vesely

Abstract

Mortality from colon cancer is significant with an expected 30,350 colon cancer deaths in 2005 with current treatment(s). Long-acting natriuretic peptide, vessel dilator, kaliuretic peptide, and atrial natriuretic peptide have significant anticancer effects in breast and pancreatic adenocarcinomas. Whether these peptide hormones have anticancer effects in colon adenocarcinoma cells and whether these effects are specifically mediated by cyclic GMP has not been determined. These peptide hormones were evaluated for anticancer effects in human colon adenocarcinoma cells and to determine whether their anticancer effects are specifically mediated by cyclic GMP. There was a 89-97% decrease (p <0.001 for each) in colon adenocarcinoma cells within 24 h with 1 mM of these peptide hormones. There was a significant (p <0.05) decrease in human colon cancer cell number with each 10-fold increase in concentration from 1 to 1,000 microM (i.e., 1 mM) of these four peptide hormones without any proliferation in the 3 d following this decrease. These same hormones decreased DNA synthesis 65-83% (p <0.001). Cyclic GMP antibody inhibited 75- 80% of these peptides' ability to decrease colon adenocarcinoma cell number and inhibited 92-96% of their DNA...Continue Reading

Citations

Apr 9, 2009·Histochemistry and Cell Biology·Matthew D BurgessWilliam R Gower
Mar 28, 2013·Endocrine-related Cancer·David L Vesely
Jun 5, 2014·World Journal of Surgical Oncology·Jia ZhangJiansheng Wang
Aug 23, 2008·European Journal of Clinical Investigation·E J EichelbaumD L Vesely
Oct 13, 2006·European Journal of Clinical Investigation·B A VeselyD L Vesely
Sep 25, 2016·Protein Expression and Purification·Mahdi AbbasianReza Zareie
Apr 27, 2010·European Journal of Clinical Investigation·A LenzD L Vesely
Aug 28, 2009·American Journal of Physiology. Cell Physiology·Abdel A Alli, William R Gower
Jan 21, 2020·Cancer Science·Takaaki MasudaKoshi Mimori
Nov 26, 2010·Current Opinion in Gastroenterology·Kris A Steinbrecher, Mitchell B Cohen
Feb 15, 2013·Experimental and Therapeutic Medicine·William P SkeltonDavid L Vesely
Jan 18, 2013·American Journal of Physiology. Renal Physiology·Lai-Jing GuoHui-Fang Bao
Jun 10, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Prasanna K SanthekadurArun J Sanyal
Nov 16, 2007·The American Journal of the Medical Sciences·Brian A VeselyDavid L Vesely

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