Four-Repeat Tauopathies: Current Management and Future Treatments.

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Lawren VandeVredeAdam L Boxer

Abstract

Four-repeat tauopathies are a neurodegenerative disease characterized by brain parenchymal accumulation of a specific isoform of the protein tau, which gives rise to a wide breadth of clinical syndromes encompassing diverse symptomatology, with the most common syndromes being progressive supranuclear palsy-Richardson's and corticobasal syndrome. Despite the lack of effective disease-modifying therapies, targeted treatment of symptoms can improve quality of life for patients with 4-repeat tauopathies. However, managing these symptoms can be a daunting task, even for those familiar with the diseases, as they span motor, sensory, cognitive, affective, autonomic, and behavioral domains. This review describes current approaches to symptomatic management of common clinical symptoms in 4-repeat tauopathies with a focus on practical patient management, including pharmacologic and nonpharmacologic strategies, and concludes with a discussion of the history and future of disease-modifying therapeutics and clinical trials in this population.

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Citations

Oct 11, 2020·Biomedicines·Jacopo Meldolesi
Jan 17, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Caroline M Tanner, Jill L Ostrem
Aug 25, 2021·Nature Reviews. Neurology·Maria StamelouGünter U Höglinger

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Methods Mentioned

BETA
sedation
MDS
cognitive behavioral therapy
glycosylation
Acetylation
ubiquitination
transgenic
antisense

Clinical Trials Mentioned

NCT02862210
NCT00703677
NCT03260920
NCT04014387
NCT00328874
NCT00532571
NCT00382824
NCT01537549
NCT00605930
NCT00211224

Software Mentioned

PASSPORT
DICE
TAUROS

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